Venal Origins is a comparative and historical study of the roots of spatial inequalities in Spanish America. The book focuses on the Spanish colonial administration and the eighteenth-century practice of office-selling – where colonial positions were exchanged for money – to analyze its lasting impact on local governance, regional disparities, and economic development. Drawing on three centuries of rich archival and administrative data, it shows how office-selling exacerbated venality and profit-seeking behaviors among colonial officials, fostering indigenous segregation, violent uprisings, and the institutionalization of exploitative fiscal and labor systems. The enduring legacies from their rule remain visible today in the form of subnational authoritarian enclaves, localized cycles of violence, and marginalized indigenous communities, which have reinforced and deepened regional inequalities. By integrating perspectives from history, political science, and economics, Venal Origins provides a nuanced and empirically grounded analysis of how colonial officials shaped – and still influence – subnational development in Spanish America.