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Chapter 58 - Prophylactic Bilateral Salpingo-oophorectomy

from Section 12 - Miscellaneous

Published online by Cambridge University Press:  24 November 2021

By
Ballari Ghosh ,
Alex Glover  and
Edward Prosser-Snelling
Edited by
Tahir Mahmood ,
Charles Savona-Ventura ,
Ioannis Messinis  and
Sambit Mukhopadhyay
Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
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Summary

Ovarian cancer is the second most common gynaecological malignancy but is the most common cause of gynaecological cancer death. Ovarian cancer screening has not been proven to be associated with statistically significant reduction in mortality from ovarian cancer. However, evidence demonstrates that prophylactic bilateral salpingo-oophorectomy significantly reduces the risk of developing gynaecological and breast cancer in women who carry BRCA1 and BRCA2 mutations.

Moreover, there is 4–20% incidence of histological diagnosis of occult ovarian malignancy found after prophylactic surgery. Identifying and counselling patients with hereditary conditions that predispose them to higher chance of breast and gynaecological cancer is extremely important. Clinical information should include protective measures, fertility implications, surgical premature menopause and its short- and long-term implications and availability of hormone replacement therapy.

Keywords

salpingo-oophorectomyprophylacticcancerhysterectomy
Type
Chapter
Information
The EBCOG Postgraduate Textbook of Obstetrics & Gynaecology
Gynaecology
 , pp. 499 - 502
Publisher: Cambridge University Press
Print publication year: 2021

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References

Chen, S, Parmigiani, G. Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol 2007;25:1329–1333.CrossRefGoogle ScholarPubMed
Dowdy, SC, Stefanek, M, Hartmann, LC. Surgical risk reduction: prophylactic salpingo-oophorectomy and prophylactic mastectomy. Am J Obstet Gynecol 2004;191:1113–1123.Google Scholar
Domchek, SM, Friebel, TM, Singer, CF, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 2010;304:967–975.Google Scholar
Manchanda, R, Abdelraheim, A, Johnson, M, et al. Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status. BJOG 2011;118:814–824.CrossRefGoogle ScholarPubMed
Jacobs, IJ, Parmar, M, Skates, SJ, Menon, U. Ovarian cancer screening: UKCTOCS trial – authors’ reply. Lancet 2016;387:2603–2604.Google Scholar
Buys, SS, Partridge, E, Black, A, et al. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 2011;305:2295–2303.Google Scholar
Bolton, KL, Chenevix-Trench, G, Goh, C, et al. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA 2012;307:382–390.CrossRefGoogle ScholarPubMed
Barrow, E, Robinson, L, Alduaij, W, et al. Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations. Clin Genet 2009;75:141–149.CrossRefGoogle ScholarPubMed
Olivier, M, Goldgar, DE, Sodha, N, et al. Li–Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. Cancer Res 2003;63:6643–6650.Google Scholar
Collaborative Group on Epidemiological Studies of Ovarian Cancer. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet 2008;371:303–314.CrossRefGoogle Scholar
Whittemore, AS, Harris, R, Itnyre, J. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II Invasive epithelial ovarian cancers in white women Collaborative Ovarian Cancer Group. Am J Epidemiol 1992;136:1184–1203.CrossRefGoogle ScholarPubMed
Kindelberger, DW, Lee, Y, Miron, A, et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 2007;31:161–169.Google Scholar
Jordan, SJ, Cushing-Haugen, KL, Wicklund, KG, Doherty, JA, Rossing, MA. Breast-feeding and risk of epithelial ovarian cancer. Cancer Causes Control 2012;23:919–927.Google Scholar
Sasieni, PD, Duffy, SW, Cuzick, J. Ovarian cancer screening: UKCTOCS trial. Lancet 2016;387:2602.CrossRefGoogle ScholarPubMed
Jacobs, IJ, Menon, U, Ryan, A, et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet 2016;387:945–956.CrossRefGoogle ScholarPubMed
Holmberg, L, Iversen, OE, Rudenstam, CM, et al. Increased risk of recurrence after hormone replacement therapy in breast cancer survivors. J Natl Cancer Inst 2008;100:475–482.CrossRefGoogle ScholarPubMed
Stubbs, C, Mattingly, L, Crawford, SA, et al. Do SSRIs and SNRIs reduce the frequency and/or severity of hot flashes in menopausal women? J Okla State Med Assoc 2017;110:272–274.Google ScholarPubMed
Foulkes, WD, Metcalfe, K, Sun, P, et al. Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. Clin Cancer Res 2004;10:2029–2034.Google Scholar
Boyd, J, Sonoda, Y, Federici, MG, et al. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA 2000;283:2260–2265.CrossRefGoogle ScholarPubMed
Watson, P, Vasen, HF, Mecklin, JP, Jarvinen, H, Lynch, HT. The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. Am J Med 1994;96:516–520.CrossRefGoogle ScholarPubMed
Powell, CB, Kenley, E, Chen, LM, et al. Risk-reducing salpingo-oophorectomy in BRCA mutation carriers: role of serial sectioning in the detection of occult malignancy. J Clin Oncol 2005;23:127–132.Google Scholar

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