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Researchers and parents alike have long assumed that experiences that occur during infancy are fundamental to both behavioral and cognitive development. Paradoxically, not only do adults typically fail to recall events that occurred prior to the age of 3, but until the middle part of the twentieth century, there was limited evidence of long-term retention during the infancy period itself. By way of example, although acquiring our first words or taking our first steps was undoubtedly monumental at the time it occurred, we have no conscious recollection of achieving these milestones. In contrast, our memories of other important achievements that took place slightly later in development, like our first day of school or the first time we rode a bike without training wheels, often survive the test of time and eventually form part of our autobiography.
This chapter describes the design, theoretical rationale, and validation of the Cambridge Neuropsychological Test Automated Battery (CANTAB). The utility of the battery for functional neuroimaging studies is examined, based on its links with animal neuropsychological research, its decomposition of complex tests of cognition into their constituent parts, and its validation in patient groups with defined brain lesions. The CANTAB has now been used quite extensively in the testing of patients with Alzheimer's disease and other forms of dementia. Two CANTAB tests specifically target spatial working memory functions, the spatial span and the self-ordered spatial working memory tasks. Both have been used in the context of positron emission tomography (PET) scanning to resolve a number of theoretical issues concerning the organization of working memory within the frontal lobe. In the CANTAB, short-term visual recognition memory is assessed using the delayed-matching-to-sample (DMTS) task.
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