Analysis of the projectile points from the Arroyo Seco 2 site allows us to evaluate their design and use from the Early to the Late Holocene in the Pampas region. The Arroyo Seco 2 projectile points are associated with events of interpersonal violence as well as hunting. Based on the techno-morphological and typological analysis and the interpretation of weapon systems, it enables us to establish differences and similarities of several point designs. The results are integrated with projectile point information from other sites in the eastern Pampas to develop a chronological sequence from the Late Pleistocene through the Holocene of projectile designs that were used throughout the period.