Plastics have come to symbolize the lifestyle and technological advancements of the 20th century, representing modern convenience and progress. In recent years, global plastic production surpassed 360 million tons in 2018 and is projected to reach between 500 and 600 million metric tons by 2025. This plastic accumulates as waste in freshwater, marine and land environments, leading to habitat disruption, alterations in nutrient cycles and harm to wildlife through exposure to toxic substances, entanglement and ingestion which pose significant ecological and health risks. The long-term ecological changes resulting from this pollution are likely irreversible. Developing countries in the Global South, including Bangladesh, are particularly vulnerable to the challenges of poorly managed plastic waste due to a lack of institutional, financial and technical resources to combat plastic pollution. The Aquatic Zoology Research Group has focused on addressing plastic pollution in Bangladesh and adopted a comprehensive strategy to tackle plastic pollution, starting with identifying the issue through various methods, followed by a thorough assessment of the plastic pollution situation and finally proposing solutions for mitigation. Our review of the current state of plastic pollution in Bangladesh’s aquatic systems highlighted significant research gaps, despite the country’s early ban on plastic bags. As a conservation research team from a developing nation facing the severe impacts of plastic pollution, we studied and listed specific expectations for the upcoming INC 5.2 meeting, highlighting challenges faced by many similar countries. We hope that INC 5.2 will move beyond mere statements to implement concrete and equitable actions.