To compare two high-resolution computerised tomography based pre-surgical planning software in measuring the cochlear dimensions, which can aid in designing/choosing customised cochlear implant electrodes.

A cross-sectional-observational study was conducted in a tertiary care centre using high-resolution computerised tomography–supported software Otoplan and curved multi-planar reconstruction to find cochlear duct length’s maximum and minimum width/diameter and height in 110 ears (55 subjects). Measurements and the time taken by both techniques were compared.

There were no significant differences in the measurements taken with the two software; however, the time taken for analysis was significantly higher for curved multi-planar reconstruction than with Otoplan.

The steep learning curve, the need for an expert radiologist and the difficulty of use are factors that significantly limit the use of curved multi-planar reconstruction. Otoplan requires less time and can be operated even by someone with less expertise in measuring cochlear dimensions for pre-surgical planning and research.

Bipolar disorder (BD) is a recurrent chronic disorder characterised by fluctuations in mood and energy disposition. Diseases could lead to degenerative alterations in brain structures such as corpus callosum (CC). Studies demonstrated that abnormalities in CC are associated with BD symptoms. The present study aims to analyse the CC of the patients with statistical shape analysis (SSA) and compare the findings with healthy controls.

Forty-one BD patients and 41 healthy individuals in similar age groups, which included 23 female and 18 male subjects, participated in the study. CC was marked with landmarks on the mid-sagittal images of each individual. The mean ‘Procrustes’ point was calculated, and shape deformations were analysed with thin-plate spline analysis.

Significant differences were observed in the shape of CC between the two groups, where maximum CC deformation was observed in posterior region marks in BD patients. There was no significant difference between the CC area of the BD patients and controls.

CC analysis conducted with SSA revealed significant differences between patients and healthy controls. The study findings emphasised the abnormal distribution of white matter in CC and the variable subregional nature of CC in BD patients. This study may enable the development of more targeted and effective treatment strategies by taking into account biological factors and understanding the differences in the brain regions of individuals with BD.