From 1493 to 1507, Hernando de Talavera, the first archbishop of Granada after the Spanish Reconquista, ran a residential school for Morisco noble boys in his palace. This article argues that Talavera’s school set the foundation for the long history of residential schooling as a tool to transform or eradicate a conquered culture through the cultural assimilation of children. A champion of Christian humanism, Talavera thought that cultivating good manners (that is, adopting Spanish customs) was the main marker of a true Christian. Thus, his pedagogy aimed to educate everyone, particularly Morisco children, in what he considered the most reasonable and natural ways of living. By examining Talavera’s spiritual pedagogy, his humanist influences, and the educational experiences of Morisco boys at his palace, this paper lays the groundwork for a genealogical study of modern European colonial residential schooling for non-European children.