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Various key events characterise experiences in later life, such as retirement, bereavement, caregiving, developing long-term conditions and hospital admission. Given their potential to disrupt lives, such events may affect older people’s mental health, but research on the associations between such events and depression has produced inconsistent findings.
Aims
To investigate the impact of key events in later life on depression trajectories in a representative cohort of people aged 50–69 in England.
Method
Our sample draws on 6890 respondents aged 50–69 in Wave 1 (2002/2003) of the English Longitudinal Study of Ageing, following them through to Wave 9 (2018/2019). We measured depression using the eight-item Center for Epidemiological Studies Depression scale. Later life events included retirement, spouse/partner death, becoming an unpaid caregiver, developing a limiting long-term illness and hospital admissions because of a fall or non-fall causes. Piecewise mixed-effects logistic regression models tested for changes in the trajectories of depression before and after each event.
Results
Statistically significant improvements in the trajectory of depression were observed following spousal bereavement, one’s own retirement and hospital admission because of causes other than falls, with reductions in the odds of depression of 48% (odds ratio: 0.52 (95% CI: 0.44–0.61)), 15% (0.85 (0.78–0.92)) and 4% (0.96 (0.94–0.99)), respectively. No changes were associated with developing a limiting long-term illness, becoming an unpaid caregiver or following spousal retirement or a hospital admission because of a fall.
Conclusions
The findings highlight the relative resilience among older adults in England in terms of depression following key later life events. There is still a role to play in delivering mental health support for older people following such events, particularly by improving the identification of those at risk of certain events as part of a broader strategy of prevention. Findings also underscore the importance of partner/spousal circumstances on individual mental health.
Population ageing, increased immigration and strained public resources will challenge the future provision of formal older-age care. Despite growing diversity in older populations across Western countries, evidence on health-care utilization among older immigrants remains limited. Using full-population registry data from Norway (2011–2016) for individuals aged 60+, we examined transitions into home health care (HHC) and intensity of use (hours/day) by immigrant background. Across all country-of-origin groups, immigrants had lower odds of transitioning into HHC than natives, with differences narrowing as duration of residence increased. A broad socio-demographic patterning to HHC transitions generally held across the country background groupings. Higher transition likelihoods were observed for individuals with lower education, lower income, living alone, and residing in less urban areas. Childlessness was linked to higher relative transition propensities among natives and Nordic immigrants, but lower relative propensities among Western-origin and Eastern European immigrants. Among non-Western immigrants, childlessness appeared to have little influence on transition propensities. For HHC intensity, only non-Western immigrants received significantly fewer hours of care than natives. Subsequent analysis indicated that this difference was entirely contingent on living alone: Only non-Western immigrants living alone had significantly fewer hours of care than natives (living alone or otherwise). These findings highlight clear variation in HHC utilization by immigrant background and socio-demographic characteristics. Future research should investigate whether lower HHC use among older immigrants reflects reduced need or barriers to access. It will also be important to assess how compositional changes in the immigrant population may influence future patterns of HHC utilization.
The 58th Annual Scientific Conference of the Nutrition Society of New Zealand, held in Christchurch in 2024, brought together 187 delegates under the theme “Kotahitanga: Bridging Research, Industry, and Practice”. This theme reflected the Society’s commitment to uniting diverse sectors to address key nutrition challenges across the life course. Kotahitanga refers to unity and collective action. Topics included nutrition in ageing and chronic disease, infant and toddler nutrition, gut health, sustainable food systems, and food safety. Presentations on sarcopenia and Parkinson’s disease emphasised the need for greater awareness and tailored nutrition strategies for older adults. The Muriel Bell Lecture celebrated the legacy of New Zealand’s first State Nutritionist and called for continued leadership in evidence-based nutrition and encouraged nutritionists to communicate research to the public. A panel on science communication offered practical strategies for engaging the public and countering misinformation. The conference reinforced the importance of collaboration, advocacy, and practical application in advancing nutrition.
This study addresses a critical gap in research on public services digitalization, specifically, how technology’s role and its relationship with ageing are framed within policy discourse. While digitalization holds the promise of enhanced accessibility, streamlined bureaucracy and greater transparency, it also has the potential to exacerbate social exclusion in ageing societies. Macro-level factors such as policy frameworks and societal values play a key role in either mitigating or intensifying these risks; they shape the way critical issues are defined and which responses are deemed conceivable. The study aims to critically examine how digitalization and ageing are framed in European and Italian policy documents, and assess the implications of these narratives for older adults. Methodologically, it analyses a corpus of 29 European and Italian policy documents on public service digitalization (2010–2023). Keywords extraction identified ten documents for critical discourse analysis, which revealed a dominant narrative of technological optimism where digitalization is presented as a universal solution, with limited acknowledgment of its potential downsides. At the European level, some documents recognize the rights of older adults, though such recognition remains sparse. Italian policies, in contrast, tend to prioritize technical and economic aspects, with little or no attention to digital exclusion or inequality. This study sheds light on how policy discourse can obscure structural inequalities and calls for more inclusive, reflective approaches to digitalization in ageing societies. It argues that policy discourse should be leveraged not only to promote innovation but also to foster social change and reduce exclusion among older adults.
La présente étude de méthode mixte explore les perceptions et attentes relatives aux hypnotiques et produits de santé naturels (PSN) chez les personnes âgées. Vingt-quatre personnes d’en moyenne 76 ans dont 58 % étaient des femmes ont participé à des entrevues semi-structurées. La moitié était des utilisateurs d’hypnotiques. Selon leur score de l’index de sévérité de l’insomnie, 54 % des participants avaient une insomnie légère, 38 % modérée et 8 % sévère. Les participants s’attendaient que les médicaments permettent un endormissement rapide, un sommeil ininterrompu et une augmentation de sa durée. Ils souhaitaient avoir des sensations comme la détente ou l’absence de pensées durant leur sommeil. Les sensations désirées au réveil comprenaient le calme, le bien-être et la satisfaction. Dans l’analyse de combinaison, les thèmes de la quantité de sommeil et le temps de latence court sont des critères d’efficacité les plus fréquemment cités autant chez ceux souffrant d’insomnie légère que modérée à sévère. L’absence d’éveils nocturne était l’autre critère d’efficacité plus fréquemment mentionné chez ceux ayant une insomnie légère alors que la sensation de bien-être au réveil était celui pour ceux ayant une insomnie modérée à sévère.
Age is the main risk factor for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia. Despite our limited understanding of cellular mechanisms of ageing-associated neuronal loss, an increasing number of studies demonstrate that oxidative stress and inflammation are key drivers. Epidemiological studies indicate that diet during middle adulthood can influence the risk of developing neurodegenerative diseases later in life, so it is important to investigate dietary interventions to combat oxidative stress and inflammation. In this study, we hypothesised that treatment with fucoxanthin, a marine carotenoid with strong antioxidant properties, prevents ageing-associated oxidative stress that is known to be related to natural brain ageing. Treatment with fucoxanthin protected rat primary hippocampal neurons against oxidative stress and ageing in vitro. In our in vivo study, middle-aged male Sprague-Dawley rats were gavaged with fucoxanthin (1 mg/kg, 5 d/week, n 6) or vehicle (n 6) for 4 weeks. After supplementation was completed, brain samples were harvested and subjected to quantitative and bioinformatic analyses. Fucoxanthin was detected and shown to decrease lipid peroxidation in the brains of the animals supplemented with fucoxanthin. Microarray analysis showed that treatment with fucoxanthin changed 5602 genes. Together, our results suggest that treatment with fucoxanthin prevents ageing-associated oxidative stress and is capable of regulating genes that potentially ameliorate age-related changes to the brain.
AI-assisted methodologies captured lived experiences and enhanced innovation practices, supporting practitioners, policymakers, and researchers in designing ageing technology. This study examined AI-assisted methods, leveraging open conversations with 30 seniors to address the complexities of ageing and technology in Singapore. Using prompt engineering, we analysed coded data with role-based, context-providing, and information-seeking prompts, generating Python code for clustering analysis. The focus was on seniors’ perceptions of technology and health concerns, revealing 25 indicators across six health dimensions. Of these, 12 social-emotional determinants influenced perceptions through emotional support and social interaction on technology adoption. Our analysis produced a four-cluster typology, providing a systematic framework to categorise perception patterns and address seniors’ diverse needs.
Endothelial progenitor cells (EPCs) are key regulators of vascular homeostasis in both health and disease, playing a crucial role in regenerating the human vascular lining throughout life. These circulating cells can differentiate into mature endothelial cells and are increasingly recognized as important biological markers of vascular function and cumulative risk for various diseases, including cardiovascular conditions. In recent decades, the role of EPCs, particularly the endothelial colony-forming cells (ECFCs) subtype, in pregnancy-related disorders and maternal and neonatal endothelial health has garnered significant attention. Evidence suggests that ECFCs may serve as predictor of future endothelial health in women and their offspring following pregnancy complications, making them particular relevant for research and therapeutic applications in adulthood, as well as potential indicators of vascular health. This review summarizes the evidence on EPCs, specifically ECFCs, as biomarkers of endothelial health in pregnancy, pregnancy-related diseases and ageing, with a focus on maternal and foetal endothelial abnormalities that may serve as prognostic factors for the development of future diseases.
Social determinants of health (SDH) impact older adults’ ability to age in place, including their access to primary and community care services. Yet, older service users are infrequently consulted on the design and delivery of health services; when they are consulted, there is scant recruitment of those who are Indigenous, racialized and/or rural. This study aimed to identify SDH for socially and culturally diverse community-dwelling older adults and to understand their views on how primary and community care restructuring might address these SDH. We recruited a diverse group of 83 older adults (mean = 75 years) in Western Canada and compared quantitative and qualitive data. The majority resided rurally, identified as women, lived with complex chronic disease (CCD), had low income and/or lived alone; nearly a quarter were Indigenous or Sikh. Indigenous status correlated with income; gender correlated with income and living situation. Thematic analysis determined that income, living situation, living rurally, Indigenous ancestry, ethno-racial minority status, gender and transportation were the main SDH for our sample. Income was the most predominant SDH and intersected with more SDH than others. Indigenous ancestry and ethno-racial minority status – as SDH – manifested differently, underscoring the importance of disaggregating data and/or considering the uniqueness of ‘BIPOC’ groups. Our study suggests that SDH models should better reflect ageing and living rurally, that policy/decision makers should prioritize low-income and ethno-racial minority populations and that service providers should work with service users to ensure that primary and community care (restructuring) addresses their priorities and mitigates SDH.
The global population is ageing rapidly, emphasising the need to understand the decision-making processes of older adults regarding potential care transitions. Gerontological research has focused on healthcare decisions, with less information on living situation choices of older adults. This review explored older adults’ experiences with their involvement in decision-making processes related to transitioning into care facilities in the United Kingdom. From a systematic search of articles, nine were reviewed using thematic narrative synthesis. Four themes with nine subthemes were identified: Involvement in decision-making (Exclusion of older adults, Usefulness of involvement), The necessity of moving (Triggers for moves, The role of family), Timely planning (Helpfulness of planning, Planning avoidance), and Factors for choosing a care home (Non-quality factors, Quality factors, Continuity of life). These themes highlighted the issue of inadequate involvement of older adults in decision-making, often resulting in negative consequences like regret and difficulty settling into new care settings. The necessity of moving arose from sudden events or increased support needs. Some older adults acknowledged the necessity due to declining health or to spare family burden, while relatives grappled emotionally, postponing the choice. Timely planning was found to be beneficial practically and emotionally, facilitating smoother transitions. However, participants would rarely plan and discuss such matters early. Older adults focused on personal experiences and trusted sources rather than publicly available information when considering Factors for choosing a care home. The findings show the need for greater inclusion of older adults in decisions related to their care and the importance of early planning and providing preferred types and formats of information to aid decisions. Future research should focus on a better understanding of older adults’ preferences for successful involvement in care decisions, with support and guidance for others involved in the decisions.
The ageing population is anticipated to encounter several challenges related to sustainability. While policies such as ageing in place can benefit older adults in terms of familiarity and independence, these policies can also lead to increased social isolation. To facilitate ageing in the right place, it is crucial to understand how the design of environments promotes social sustainability. This article presents a scoping review of empirical research focused on the characteristics of housing and surrounding environments that support social integration, cohesion and participation of older adults. The search strategy was conducted in five databases, resulting in 20,477 articles. After screening 7,550 titles and abstracts based on predetermined inclusion and exclusion criteria, 19 articles were selected. The findings of these articles are presented across three themes: (1) housing environments, (2) environments beyond the home and (3) the social environment. Although there is no one-size-fits-all housing model for older adults, the authors suggest that ageing in place policies should be reconceptualized as ageing in ‘places’ and ‘spaces’, emphasizing the diversity of social needs of older adults. Understanding the environmental characteristics, the role of accessible and safe environments beyond the home, and how people and culture support a sense of belonging provides a policy direction for how to design socially sustainable environments for older adults in the future.
The RDA for dietary protein is likely insufficient for individuals with cystic fibrosis (CF). This study sought to characterise protein intake and diet quality in adults with cystic fibrosis (awCF), before and after elexacaftor/tezacaftor/ivacaftor (ETI) therapy, compared with healthy controls. Dietary intake was assessed by diet diary in awCF at baseline (BL, n 40) and at follow-up > 3 months post ETI therapy (follow-up (FUP), n 40) and in age-matched healthy controls (CON, n 80) free from known disease at a single time point. Protein intake dose and daily distribution, protein quality, protein source and overall diet quality were calculated for each participant. Both CON (1·39 (sd 0·47) g·kg–1·day–1) and CF (BL: 1·44 (sd 0·52) g·kg–1·day–1, FUP: 1·12 (sd 0·32) g·kg–1·day–1) had a higher mean daily protein intake than the protein RDA of 0·75g·kg–1·day–1. There was a significant reduction in daily protein intake in the CF group at FUP (P = 0·0003, d = 0·73), with levels below the alternative suggested dietary intake of ≥ 1·2 g·kg–1·day–1. There were no sex differences or noticeable effects on protein quality or source following the commencement of ETI therapy when compared with CON (all P > 0·05), although overall diet quality decreased between time points (P = 0·027, d = 0·57). The observed reduction in daily protein intake in the present cohort emphasises the importance of ensuring appropriate dietary protein intake to promote healthy ageing in adults with CF. More research is needed to evidence base dietary protein requirements in this at-risk population.
Menopause is an inflection point in the ageing trajectory. Independent of chronological age, menopause is associated with the biological ageing of several body systems. In this review, we highlight the importance of considering the influence of menopause – its types, symptoms and interventions – on brain health. Supplementing the loss of ovarian hormones with menopausal hormone therapy (MHT) may be key for supporting the healthy brain ageing of females. MHT has been associated with reduced risk of several neurodegenerative diseases; however, its benefits are not always observed on brain health.
Aims
This narrative review highlights often overlooked MHT factors that influence its effects to produce positive or negative effects on brain health, cognition and neurodegenerative disease risk. These factors include the many varieties of MHT, including formulation, administration route and dosing schedule, as well as individual characteristics, particularly the presence of vasomotor symptoms and apolipoprotein ε4 (APOE4) genotype.
Method
PubMed and Scopus were used to identify articles with relevant search terms.
Results
Menopause factors, including age, abruptness and symptoms, influence brain ageing. MHT influences brain health, with transdermal MHT showing more positive effects on brain ageing, but its effectiveness may depend on individual factors such as genotype, reproductive and lifestyle factors.
Conclusions
To develop effective and individualised MHT treatments, further research is needed. Preclinical models must consider the type of human menopause and MHT. To achieve the greatest dementia prevention in females, more menopause education and care is needed that extends beyond 60 years of age, or 10 years postmenopause.
We focus on obtaining Block–Savits type characterizations for different ageing classes as well as some important renewal classes by using the Laplace transform. We also introduce a novel approach, based on the equilibrium distribution, to handle situations where the techniques of Block and Savits (1980) either fail or involve tedious calculations. Our approach in conjunction with the theory of total positivity yields Vinogradov’s (1973) result for the increasing failure rate class when the distribution function is continuous. We also present simple but elegant proofs for Block and Savits’ results for the decreasing mean residual life, new better than used in expectation, and harmonic new better than used in expectation classes as applications of our approach. We address several other related issues that are germane to our problem. Finally, we conclude with a short discussion on the issue of convolutions.
This study explores retirement processes. State pension age is gradually increasing in many countries, including the Netherlands. The traditional retirement pathway where individuals have a cliff-edge transition from a full-time job with a permanent contract to full retirement appears to be applicable to an ever-smaller group of employees. Hence, more recently, ‘retirement’ is viewed not as a single transition out of the labour force but rather as a process determined by several intertwined contractual and financial aspects of the labour market. Research has hardly ever combined labour market aspects such as employment security (type of employment contract), financial security (income), work-time arrangements (hours worked) and social protection (receipt of pension and other benefits). This study aims to address this knowledge gap using register data from Statistics Netherlands and treating the status of individuals before and immediately after retirement as a latent variable (late employment quality [LEQ]) measured by several indicators: contract type, contractual working hours, self-employment, income and different types of benefits including pension. We follow older workers between 2008 and 2019 for at least four years before and two years after state pension age and derive trajectories of LEQ using a mixture hidden Markov model. The results indicate several avenues: ‘retirement with medium/high pension’, ‘from non-employment to low pension’, ‘eventually partial retirement’, ‘steps from employment to low pension’ and ‘alternating work and non-work’. It seems to be the case that most older workers in the Netherlands cannot simply be categorised as having either cliff-edge transitions or atypical retirement.
Japan is shrinking. Current projections indicate a population decrease of around one quarter by mid-century. Depopulation is potentially good news, providing opportunities for reconfiguring living conditions and alleviating human-environmental pressures. Nevertheless, ageing and depopulation have outcomes that require adjustment. One of these is spatial inequalities, which have been accelerating since the 1990s. Japan is the Asia-Pacific’s pioneer ageing and shrinking society. In East Asia both China and South Korea are ageing and expected to begin shrinking soon. Even high immigration Anglophone countries such as New Zealand are experiencing post-growth demographic processes at subnational level. Japan’s significance is in how adaptive responses there inform prospects for others as they experience their own post-growth pathways. This article presents case studies of Sado Island in Japan and New Zealand’s South Island in a comparative qualitative analysis of rural agency under population decline. Overall, I contend there is potential for benefitting from demographic shrinkage - what I term a ‘depopulation dividend’ - and for rural regions in the Asia-Pacific to progress towards a sustainable post-growth economy and society.
The rising incidence of neurodegenerative diseases in an ageing global population has shifted research focus towards modifiable risk factors, such as diet. Despite potential links between dietary patterns and brain health, inconsistencies in neuroimaging outcomes underscore a gap in understanding how diet impacts brain ageing. This study explores the relationship between three dietary patterns – Mediterranean, Dietary Approaches to Stop Hypertension (DASH) and Mediterranean-DASH Intervention for Neurodegenerative Delay – and cognitive outcomes as well as brain connectivity. The study aimed to assess the association of these diets with brain structure and cognitive function, involving a middle-aged healthy group and an older cohort with subjective cognitive decline. The study included cognitive assessments and diffusion-weighted MRI data to analyse white matter microstructural integrity. Participants comprised fifty-five older individuals with subjective cognitive decline (54·5 % female, mean age = 64) and fifty-two healthy middle-aged individuals (48·1 % female, mean age = 53). Age inversely correlated with certain cognitive functions and global brain metrics, across both cohorts. Adherence to the Mediterranean, DASH and Mediterranean-DASH Intervention for Neurodegenerative Delay diets showed no significant cognitive or global brain metric improvements after adjusting for covariates (age, education, BMI). Network-based statistics analysis revealed differences in brain subnetworks based on DASH diet adherence levels in the subjective cognitive decline cohort. In the healthy cohort, lower white matter connectivity was associated with reduced adherence to Mediterranean-DASH Intervention for Neurodegenerative Delay and DASH diets. Ultimately, the study found no strong evidence connecting dietary patterns to cognitive or brain connectivity outcomes. Future research should focus on longitudinal studies and refine dietary assessments.
Accelerated ageing indexed by telomere attrition is suggested in schizophrenia spectrum- (SCZ) and bipolar disorders (BD). While inflammation may promote telomere shortening, few studies have investigated the association between telomere length (TL) and markers of immune activation and inflammation in severe mental disorders.
Methods:
Leucocyte TL defined as telomere template/amount of single-copy gene template (T/S ratio), was determined in participants with SCZ (N = 301) or BD (N = 211) and a healthy control group (HC, N = 378). TL was analysed with linear regressions for associations with levels of 12 immune markers linked to SCZ or BD. Adjustments were made for a broad range of potential confounding variables. TL was measured by quantitative polymerase chain reaction (qPCR) and the immune markers were measured by enzyme immunoassays.
Results:
A positive association between levels of soluble tumour necrosis factor receptor 1A (sTNF-R1) and TL in SCZ (β = 0.191, p = 0.012) was observed. Plasma levels of the other immune markers were not significantly associated with TL in the BD, SCZ or HC groups.
Conclusion:
There was limited evidence of association between immune markers and TL in SCZ and BD. The results provide little support for involvement of immune dysregulation, as reflected by current systemic markers, in telomere attrition-related accelerated ageing in severe mental disorders.
Discourses and how they construct policy ‘problems’ delimit ‘solutions’, including the scale, shape and structure of services. This article discusses how the adult social care sector in England is presented as a policy problem, with the greater use of technology the associated ‘common-sense’ solution – both to the ‘crisis of care’ in a society with an ageing population and as a means to stimulate the national economy. It draws upon critical discourse analysis to examine English policy documents and other government texts published between 2020 and 2022. In doing so, it de-objectivises and de-universalises semiotic claims around care and technology and explores omitted alternatives. In discourse, ageing and care are framed as both problems to be solved and opportunities for entrepreneurship. Technologies are bound together with efficiency, with limited exploration of how use of the former necessarily entails the latter. Technology is, in addition, presented as agentic, inevitable and unassailable, closing off debates as to whether other, less seemingly ‘innovative’ options for reform and change could entail more favourable outcomes. Discourse thus limits the role of the state to stimulating the environment required for technological advancement.