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Chapter 2 describes the original concepts and related research of the author Brave Heart and Indigenous colleagues. The new operationalization of historical trauma described in the Introduction is applied to this context, for example when it comes to discrimination, intergenerational transmission, and social pathologies. The chapter provides empirical material on, among others, the immediate consequences that fully or partially substantiate the assumptions, including assumed mediating factors of historical trauma effects such as traditional values or cultural identity. The chapter concludes by reviewing the first available studies on healing, involving an adjunct program to group therapy with traditional Indigenous content, as well as empowerment through entrepreneurship programs tailored to youth. The conclusion of the chapter is that not all the possibilities of a broader conceptualization of historical trauma in this area have been realized.