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DNA methylation plays a crucial role in gene regulation and has been implicated in various neuropsychiatric disorders, including alcohol use disorder (AUD). The rs27072 polymorphism within the SLC6A3 gene has been studied in addictive disorders; however, its role in epigenetic modifications remains unclear. This study investigates the methylation levels of CpG sites near rs27072 and their potential associations with AUD, personality traits, and environmental stressors.
Materials and methods
One hundred twenty-four male participants (66 patients with AUD and 58 controls) were analyzed for DNA methylation at CpG islands proximal to the rs27072 locus. The personality traits and life stress events were assessed in all participants.
Results
AUD patients had a lower methylation level than healthy controls (p = 0.003 for total average). However, the results changed to borderline significance after adjusting for clinical covariates in the analysis (p = 0.042), and the genotype at rs27072 did not modulate the methylation levels. There is high novelty seeking (p < 0.001), and more bad life events in patients with AUD than healthy controls (p < 0.001). Additionally, no significant correlations were found between methylation levels and personality traits or life stress scores (p > 0.05).
Conclusions
The methylation of the SLC6A3 gene may be marginally associated with AUD; however, the rs27072 genotype, personality, and life stress may not be directly linked to epigenetic modifications. Cross-sectional epigenetic studies may not establish causality; future studies with larger, more diverse cohorts and longitudinal designs are warranted to elucidate the complex interplay in AUD pathophysiology.
This study examines how unelected representation, where political activists make representative claims on behalf of self-articulated constituencies, shapes citizens’ feelings of representation. Through a cross-national conjoint experiment (Sweden, Germany, Italy, and Romania, N = 8279), we test three routes to representation: descriptive representation through demographic congruence, substantive representation through issue congruence, and psychological representation through personality-trait congruence and personality-ideology congruence. Results indicate that unelected representation makes people feel represented through these routes. Substantive representation has the strongest impact, followed by psychological representation and descriptive representation. We also find that contextual and individual factors influence how these routes operate. Ultimately, this paper presents a novel perspective on the effects of unelected representation, laying the groundwork for new empirical models of political representation that are firmly rooted in the conceptual innovations of constructivist theories. Unelected representation may have important implications for modern representative politics.
“Personality” is considered as a set of individual characteristics and behavioral dispositions based on both temperamental (partially genetic-driven) and developmental (partially culture-driven) components that are relatively stable across time and context. We suggest that these two intertwined components progressively shape autopoietic processes operating at an individual and a social level in accordance with the theory of evolution and its application to human behavior. We discuss existing evidence linking personality traits to the manifestations of personality disorders and diverse forms of psychopathology. Particular attention is dedicated to the evolutionary concept referred to as Life History Theory, considering its utility in predicting the development of personality traits. We also emphasize the need to explore sources of critique and further research, suggesting that a multifaceted approach to the understanding of personality dimensions is crucial.
There remain important questions about how personality shapes risk perceptions, willingness to engage in protective behaviors, and policy preferences during a changing pandemic. Focusing on the Big-5 and COVID-19 attitudes, we find associations between risk perceptions and negative emotionality and agreeableness, as well as between each Big-5 trait and protective behaviors and support for government restrictions. These associations are mostly stable over time, with instability pronounced for lockdown policy support, where agreeableness and conscientiousness diminish in importance as pandemic conditions improve. Negative emotionality, conscientiousness, and agreeableness reduce differences between the political left and right and between those who do and do not trust experts. We highlight the heterogeneous interplay between personality and political ideology to understand pandemic policy support, attitudes, and behaviors.
Describe key elements of adolescent identity development; evaluate the genetic, social, and cultural influences on identity; understand creativity and cultural change as parts of adolescent development.
Environmental changes can be positive in mental illness. Systematic, planned and guided environmental change in all its aspects is called nidotherapy. It has shown some benefit but has not been extended to whole communities.
Aims
A cluster-randomised step-wedge trial is planned in six village communities in Nottinghamshire, England, covering an adult population of 400.
Method
Adults in six villages will be offered a full personal environmental assessment followed by agreed change in different 3-month periods over the course of 1 year. All six villages have populations between 51 and 100 residents and are similar demographically. Assessments of mental health, personality status, social function, quality of life and environment satisfaction will be made. After the initial baseline period of 3 months, two villages will be randomised to nidotherapy for 3 months, a further two at 6 months and the last two at 9 months.
Results
The primary outcome will be change in social function; secondary outcomes include health-related quality of life, anxiety and depressive symptoms, personality status, costs of nidotherapy and life satisfaction. Adverse events will also be recorded. The analysis will be carried out using a multimodal statistical approach examining (a) the change in scores of the primary outcome (social function); (b) change in scores of all secondary outcomes, including costs; and (c) changes in environmental satisfaction.
Conclusions
The findings of this study should help to determine whether nidotherapy has a place in the early detection and treatment of mental pathology.
Chapter 8 focuses on the timescale in which the short-term timescale of activity and experience is embedded, namely, the creative artist’s life course. It discusses artistic talent, art school and training, the artist’s personality, including the relationship between psychopathology and art, the outsider phenomenon, motivation, inspiration, and drives for artistic creation, artistic identities, intersectionality, and the artistic persona, all of which are complex phenomena. The chapter also discusses the complexity of the relationship between personality and artistic creation, based on a complex dynamic systems approach to personality itself.
This study described the development and assessment of the psychometric properties of the Dissociation-Integration of Self-States Scale (D-ISS). This is a new scale to assess dissociation at the ‘between modes’ or self-state (personality) level. The D-ISS is rooted in cognitive behavioural theory and designed to measure between-mode dissociation (dissociation between self-states) in clinical practice and research.
Method:
Study 1: D-ISS scale items were generated and then answered by 344 young adults (16–25 years) who reported experiencing stressful times. An exploratory factor analysis (EFA) was conducted and the results were used to refine the scale to 25 items.
Study 2: The final 25-item D-ISS was completed by 383 adults (18–65 years) who reported experiencing mental health difficulties. A confirmatory factor analysis (CFA) was conducted using the second dataset. Internal consistency, test–retest reliability, convergent validity and divergent validity of the final D-ISS was assessed.
Results:
Study 1: The EFA showed a clear 5-factor solution, which was used to refine the D-ISS to a total of 25 items with five items in each factor.
Study 2: The 5-factor solution from Study 1 was confirmed as a good fit by the CFA using the data collected in Study 2. The D-ISS demonstrated good internal reliability and test–retest reliability. The D-ISS showed no correlations with divergent scales. For convergent validity, the D-ISS showed moderate correlations with the Dissociative Experiences Scale (DES-II).
Conclusions:
The new D-ISS measure of between-mode dissociation is reliable and valid for the population represented by our sample. Further research into its use in clinical populations is required.
Key learning aims
(1) To understand and be able to use a new measure of dissociation at the personality or self-states level.
(2) To understand the cognitive behavioural model of dissociation.
(3) To understand the theoretical underpinnings of the scale, in terms of the effects of childhood and adult adversity and other factors on psychological development.
(4) To consider the potential clinical and research applications of the scale.
(5) To appreciate the limitations of the research so far and the nature of future research required.
We experimentally subliminally prime subjects prior to charity donation decisions by showing words that have connotations of pro-social values for a very brief time (17 ms). Our main finding is that, compared to a baseline condition, the pro-social prime increases donations by approximately 10–17 % among subjects with strong pro-social preferences (universalism values). We find a similar effect when interacting the prime with the Big 5 personality characteristic of agreeableness. We furthermore introduce a novel method for testing for priming, “subliminity”. This method reveals that some subjects are capable of recognizing prime words, and the overall results are weaker when we control for this capacity.
Some of the earliest work on heterogeneity in social preferences focuses on gender differences in behavior. The source of these gender differences is the main interest of this paper. We report on dictator game experiments designed to identify heterogeneity of other-regarding preferences according to personality, gender, status, and whether the choice is framed as giving or taking. We find that the effect of gender on giving is more subtle than previously understood, and is explained collectively by various personality factors. We also find that women, high status treatment individuals, and individuals in the giving language treatment give less, and are also less sensitive to the price of giving.
This chapter of the handbook reviews empirical research on moral character, which has only recently attained a prominent role in psychology, in contrast to long traditions in ethics and education. A person’s moral character comprises their dispositions to think, feel, and act morally, and these dispositions are cross-situationally and temporally fairly consistent. Against a long-standing belief in psychology that the personality disposition of warmth most strongly influences people’s impressions of one another, the evidence suggests that moral character occupies this central position. Moral character exerts its influence on impressions quite independently of other personality traits, and it features prominently in people’s representations of their own personality as well. Moral character is also a central element in a person’s perceived identity – who the person is perceived to be “deep down.” The authors close by charting some of the features from which people infer another’s moral character, including their actions but also, critically, their mental states such as their goals and intentions.
This chapter reviews findings about the structural changes to the brain, considering effects on both gray matter and white matter and relationships between these measures and behavior. It also reviews research on changes with age to the connectivity of the brain and the default mode network. Findings related to effects of aging on perception and sensation as well as neurotransmitters are presented. The chapter ends with extensive coverage of individual difference factors, including genetic influences, intelligence, cognitive reserve, bilingualism, personality, and stress.
Most scholars agree that candidates’ use of negative campaigning is based on rational considerations, i.e., weighing likely benefits against potential costs. We argue that this perspective is far too narrow and outline the elements of a comprehensive model on the use of negative campaign communication that builds on personality traits, values, social norms, and attitudes toward negative campaigning as complementary mechanisms to classical rational choice theory. We test our theoretical assumptions using candidate surveys for twelve state elections in Germany with more than 3,100 candidates. Our results strongly suggest that negative campaigning goes beyond rational considerations. Although benefit–cost calculations are the primary driver of the decision to attack the opponent, other factors are also important and enhance our understanding of why candidates choose to engage in negative campaign communication. Our findings have important implications for research on candidate attack behavior.
Liberals experience more distress than conservatives. Why? We offer a novel explanation, the social support hypothesis. Maintaining social support and avoiding exclusion are basic human motivations, but people differ in their sensitivity to the threat of social exclusion. Among people high in the personality trait neuroticism, exclusion easily triggers feelings of vulnerability and neediness. The social support hypothesis translates this to politics. Concerned with their own vulnerability, we find that neurotic people prefer policies of care – social welfare and redistribution – but not other left-wing policies. Specifically, it is anxiety – the facet of neuroticism tapping sensitivity to social threats – that drives this link. And it is only for people experiencing exclusion that anxiety predicts support for social welfare. Our results come from two experiments and four representative surveys across two continents. They help to resolve the puzzle of liberal distress while providing a new template for research on personality and politics.
We used a survey to investigate the effects of personality, motives, and socioeconomics for drinking hard cider among 3,373 Norwegian respondents in 2023. Wine interest, cultural interest, having a high score on conspicuous attitude, or being female increased the predicted consumption frequencies of hard cider. Scoring high on the taste index, being a conscientious respondent, being older, higher educated, or believing religion is important reduced the predicted frequencies. The estimated effects were compared with the corresponding effects for red, white, and sparkling wines. Cultural interest and wine interest are the main motives for hard cider and all categories of wine.
Communication and cognition are presented as deeply interrelated aspects of the mind, the means by which animals perceive, respond to, and understand each other as well as their world. This chapter reviews chemosensory, vibrational (acoustic and seismic), visual and tactile sense modalities, the various ways in which people have attempted to exploit these sensory channels to manage problematic behaviors, and the ways in which anthropogenic disturbances and pollutants can interfere with signaling. It then delves into domains such as self-awareness, personality, problem-solving, cooperation, social learning, and culture. The chapter considers intriguing adaptive hypotheses such as that of cognitive buffering, before provoking reflection on the downstream consequences of social disturbance and trauma. Drawing on experimental studies on elephants and a range of other species from honeybees to whales, the comparative perspective positions cognitive abilities within their broader ecological and evolutionary contexts, and highlights why it is crucial to account for phenomena such as social learning and culture in protecting and managing elephant populations.
There is strong evidence for a general psychopathology dimension which captures covariance among all forms of psychopathology, yet its nature and underlying association with personality remain unclear. This study examined the co-development of general psychopathology and four high-risk personality traits: anxiety sensitivity, negative thinking, sensation seeking, and impulsivity. Data from two large Australian school-based randomised controlled trials of substance use prevention programs were analysed (N = 2,083, mean age at baseline = 13.49 years). Adolescents completed self-report measures of psychopathology symptoms and personality at baseline, one-, two-, and three-years post-baseline. Latent curve models with structured residuals, were used to examine the co-development of general psychopathology (extracted from a higher-order model) and personality traits from 13 to 16 years of age, controlling for age, sex, and cohort. Higher than usual levels of anxiety sensitivity and impulsivity were associated with higher than usual levels of general psychopathology at subsequent time points, and higher than usual levels of general psychopathology were associated with higher than usual levels of negative thinking at later time points. Sensation seeking was unrelated to general psychopathology. These findings enhance our understanding of the meaning and validity of general psychopathology, highlighting potential personality-based prevention and intervention targets.
The main question of this Element is whether God has a personality. The authors show what the question means, why it matters, and that good sense can be made of an affirmative answer to it. A God with personality - complete with particular, sometimes peculiar, and even seemingly unexplainable druthers - is not at war with maximal perfection, nor is the idea irredeemably anthropomorphic. And the hypothesis of divine personality is fruitful, with substantive consequences that span philosophical theology. But problems arise here too, and new perspectives on inquiry itself. Our cosmos is blessed with weirdness aplenty. To come to know it is nothing less than to encounter a strange and untamed God.
The revival of psilocybin in psychopharmacological research heralds a potential paradigm shift for treating mood and anxiety disorders, and other psychiatric conditions beyond the psychotic spectrum. This critical review evaluates current evidence on psilocybin’s efficacy, juxtaposing potential benefits with the practical aspects of psychedelic-assisted psychotherapy (PAP) and the methodological constraints of existing research.
An electronic literature search was conducted using PubMed/MEDLINE, selecting studies published up to December 2023 that explored the clinical use of psilocybin in mood and anxiety disorders, obsessive-compulsive disorder, post-traumatic stress disorder, and substance use disorder. Despite promising preliminary results suggesting psilocybin’s efficacy in alleviating depression and anxiety, as well as obsessions, compulsions, and addictive behaviors, significant evidence gaps persist. These include evaluating the efficacy of psilocybin compared to standard antidepressants or anxiolytic molecules and identifying patient subpopulations that might benefit most from PAP. Concerns about psilocybin’s safety, long-term efficacy, and optimal dosage remain unclear due to previous trials’ limitations. Real-world implementation faces challenges, including infrastructural requirements, personnel training, and unresolved legal and ethical issues. This paper argues for further research to substantiate the evidence base, emphasizing the need for larger studies that overcome current methodological limitations and explore psilocybin’s full therapeutic potential. While psilocybin holds promise for psychiatry, its successful translation from research to clinical practice demands more robust evidence on efficacy, safety, and methodological rigor. In addition, other factors, such as cultural stigma and legal/ethical issues, need to be successfully addressed to facilitate psilocybin’s implementation in healthcare systems.
Post-racing thoroughbreds (TBs) are increasingly being considered for Equine Assisted Services (EAS), but their use has not yet been widely characterised. This study aimed to generate detailed data on TBs and other breeds (OBs) of horses in EAS via an online survey. The survey was completed by 129 EAS practitioners from 15 countries and reported detailed data on 427 EAS equids, including 57 TBs. Most of the EAS horses were housed collectively, had access to free exercise over 12 h per day and had unrestricted access to forage. The most commonly recorded selection criteria for EAS horses consisted of: demonstrating a good personality; enjoying the work; absence of propensity to kick/bite. Detailed data gathered on individual horses showed that in comparison to OBs, TBs were younger, more likely to be a gelding, less likely to be used in ridden programmes, and tended to present more behavioural issues than OBs. The majority of the participants agreed that TBs have specific assets of particular interest to EAS programmes, such as sensitivity, body/movement characteristics or responsiveness/flight response. Finally, a large majority of participants reported that they believe TBs to be suitable for EAS programmes and some would consider working with them. These results showed TBs to already be in use in various EAS programmes and more could be incorporated in the future. In terms of animal welfare and beneficiaries’ safety, a selection process could therefore be designed and implemented to choose the most adapted horses for each EAS centre, according to living conditions and EAS activities practised (ridden or not ridden).