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Neuroticism, a personality trait linked to both cardiovascular and psychiatric disorders, has been associated with cognitive decline and increased dementia risk, though the underlying neural mechanisms remain unclear. Mapping its relationship with brain structure could provide valuable insights into neural pathways and targets for early intervention.
Methods
We examined brain-wide associations between neuroticism and structural neuroimaging metrics derived from T1-, T2-weighted, and diffusion MRI in 36,901 dementia-free UK Biobank participants. Bonferroni-significant associations underwent bidirectional two-sample Mendelian randomization to evaluate the evidence for a causal relationship. Given that neuroticism is generally stable across adulthood and challenging to modify, we assessed whether these associations were mediated by health conditions (depression, anxiety, hypertension, ischemic heart disease [IHD], and diabetes) that are both consequences of neuroticism and known risk factors for dementia, and also modifiable through widely available and efficacious therapeutic interventions.
Results
Higher neuroticism was found to be associated with reduced grey matter volumes in the frontal and limbic regions, as well as widespread differences in white matter microstructure, particularly in thalamic radiations. Genetic analyses supported a potential causal effect of neuroticism on increased diffusivity in thalamic radiations. Hypertension mediated the associations between neuroticism and both grey and white matter measures, while depression and anxiety primarily mediated associations with white matter microstructure. Contributions from IHD and diabetes were minimal.
Conclusions
Neuroticism is linked to widespread structural brain differences that contribute to poorer brain health, and targeting vascular and mental health may help mitigate its impact.
How we create believable characters. Resisting the urge to decide exactly who your character is before you know who your story needs them to be. The interdependence of character and plot and the emotional journey of the character. Moving beyond ‘show; don’t tell’: the interaction between characters allows the reader to get to know characters by observation rather than instruction. Managing minor characters. Conflict, consistency and contradiction all have a part to play in plausible characterisation. Characters come from you but they’re not you: the importance of freeing ourselves as writers from ourselves as people.
This chapter invites consideration of Bloomsbury as the Biography group. It details Bloomsbury’s founding and defining contributions to the “New Biography,” particularly in theoretical and creative works by Harold Nicolson, Virginia Woolf, and the most influential British biographer of the past century, Lytton Strachey. Focusing its attention most carefully on the latter two, it explores how both Woolf and Strachey, as “spiritual” writers of the modernist age (Woolf, “Modern Fiction”), understood biography as a means of revealing personality, while diverging on some essential matters. Woolf, whose initial understanding of biography as an art evolved into a more subdued description of it as (mere) craft, anticipated that this aim might be accomplished through archival assiduity over time by a succession of fact-bound biographers, each bringing a different perspective to facts, old and new. Strachey, for his part, who always considered biography an art form, thought such an aim might be accomplished in the present, using fictional means to reveal both the personality of the nominal biographical subject and the personality of the biographer. This chapter finally reads Strachey as the most important progenitor of biographical fiction.
Chapter 4 on Richard Feynman, my theoretical physics thesis advisor, is a collection of vignettes that reveal aspects of behavior and thought that contributed to his mystique and unique accomplishments in physics.
After relating the history behind Feynman’s V-A theory of party violation, much of it in Feynman’s own words, the rest of the chapter is based on my personal interactions with Feynman lasting for a little more than twenty years, from the time I arrived at Caltech in 1959 till I left in 1981. Feynman’s attitude towards experimental results related to parity violation provides an informative background to how he would handle experimental information related to the discovery of quarks. The intent here, and in the remainder of the Chapter, is to give the reader a sense of how Feynman thought about physics, how he practiced it, and what he valued. His struggle with constituent quarks (aces), and what to make of them, lasted considerably longer than a decade, passing though several phases, including one with partons, but eventually ending with his fully accepting their reality.
We explore how honesty-humility and the other HEXACO personality traits relate to citizens’ nascent ambition and their recruitment to run for office. We extend previous work on virtue-related personality traits and political recruitment in two important ways: we go beyond North America and conduct a five-country cross-national study with nationally representative samples. More importantly, going beyond individual-level differences in nascent ambition, we also address how honesty-humility predicts the likelihood of being asked to and actually running for office. Based on data from Canada, Denmark, Israel, the Netherlands, and Switzerland, we demonstrate that citizens with lower levels of honesty-humility are more likely to have considered running, to deem themselves qualified to run, to have been asked to run, and to actually have run for a political office. From a ‘virtue ethics’ perspective, this is highly concerning: low honesty-humility predisposes individuals to engage in unethical behavior and decision-making. We discuss implications for the quality of political representation.
Individual differences researchers investigate many kinds of psychological variation, but the most widely studied of these are personality and intelligence. Personality is defined in many ways, but one way of thinking of it is as a form of motivational system which predisposes people to seek out particular situations and respond in particular ways. Personality is measured most frequently by self-report questionnaires. These questionnaires usually describe a personality on a number of dimensions of factors (e.g. extraversion, neuroticism, psychoticism). Research using twin studies suggests that personality is moderately heritable. Theories developed to explain variation in personality have to account for both heritable and non-heritable components. It is necessary not only to understand why personality might be passed on through the genes, but also why so much of the variation in personality appears to be due to the environment. Various theories were advanced to explain both of these aspects of personality.
The need to maintain cooperation in social dilemmas is a fundamental challenge. Responses to social dilemmas are affected by dispositions toward exploitativeness (i.e., the maximization of one’s own utility) and distrust (i.e., the fear of being exploited by others). This is because the belief that others are untrustworthy justifies exploitative behaviors. The Dark Factor of Personality (D) is postulated to comprise the conjunction of these dispositions, implying that individuals will assume similarity on D. In this research, we sought to test this implication by examining whether individuals’ self- and observer reports of unacquainted targets on D converge. Across five studies, we found that individuals assume similarity on D when unknown targets are described as ‘typical’ (Study 1) or when shown a photograph (Studies 2–5). These effects were not moderated by the congruency between rater and target sex (Studies 2 and 3); however, we found that higher attractiveness of targets led to greater assumed similarity on D (Studies 4 and 5). These findings are consistent with D reflecting the conjunction of exploitativeness and distrust while also suggesting that assumed similarity on D is moderated by the interpersonal attraction of those being rated.
The life history approach to individual differences has become a major influence in evolutionary psychology, not least thanks to the contributions made by Jay Belsky and his collaborators over the last three decades. Today the approach is at a turning point, with a lively dialectic between proponents and critics and a menu of theoretical and empirical challenges to address. In this chapter, I follow up on previous work and continue to critically examine the concepts and assumptions of the “fast-slow paradigm” in evolutionary psychology. Specifically, I try to clarify some aspects of the interplay between the demographic and psychological levels of analysis, make an updated case for the centrality of the mating–parenting tradeoff in the organization of life history-related traits, describe the constellations formed by those traits, introduce the notion of multiple fast/slow profiles, and (re)consider the role of puberty timing in relation to human life history strategies. Preserving the value of the life history approach demands that we work to keep the foundations healthy – constantly revising our concepts and assumptions, in the spirit of Jay’s remarkable scientific career.
DNA methylation plays a crucial role in gene regulation and has been implicated in various neuropsychiatric disorders, including alcohol use disorder (AUD). The rs27072 polymorphism within the SLC6A3 gene has been studied in addictive disorders; however, its role in epigenetic modifications remains unclear. This study investigates the methylation levels of CpG sites near rs27072 and their potential associations with AUD, personality traits, and environmental stressors.
Materials and methods
One hundred twenty-four male participants (66 patients with AUD and 58 controls) were analyzed for DNA methylation at CpG islands proximal to the rs27072 locus. The personality traits and life stress events were assessed in all participants.
Results
AUD patients had a lower methylation level than healthy controls (p = 0.003 for total average). However, the results changed to borderline significance after adjusting for clinical covariates in the analysis (p = 0.042), and the genotype at rs27072 did not modulate the methylation levels. There is high novelty seeking (p < 0.001), and more bad life events in patients with AUD than healthy controls (p < 0.001). Additionally, no significant correlations were found between methylation levels and personality traits or life stress scores (p > 0.05).
Conclusions
The methylation of the SLC6A3 gene may be marginally associated with AUD; however, the rs27072 genotype, personality, and life stress may not be directly linked to epigenetic modifications. Cross-sectional epigenetic studies may not establish causality; future studies with larger, more diverse cohorts and longitudinal designs are warranted to elucidate the complex interplay in AUD pathophysiology.
This study examines how unelected representation, where political activists make representative claims on behalf of self-articulated constituencies, shapes citizens’ feelings of representation. Through a cross-national conjoint experiment (Sweden, Germany, Italy, and Romania, N = 8279), we test three routes to representation: descriptive representation through demographic congruence, substantive representation through issue congruence, and psychological representation through personality-trait congruence and personality-ideology congruence. Results indicate that unelected representation makes people feel represented through these routes. Substantive representation has the strongest impact, followed by psychological representation and descriptive representation. We also find that contextual and individual factors influence how these routes operate. Ultimately, this paper presents a novel perspective on the effects of unelected representation, laying the groundwork for new empirical models of political representation that are firmly rooted in the conceptual innovations of constructivist theories. Unelected representation may have important implications for modern representative politics.
The current chapter focuses on the relationships of stable, nonpathological individual differences to violent extremism. Traditionally, strong contextual forces have been viewed as overriding personal traits in determining group behavior generally and violent extremism specifically. This chapter challenges such conventional wisdom by emphasizing the role of individual differences. We argue and provide evidence that supports and highlights the interplay and complementary roles of individual psychology and social environments in shaping violent extremism. We review recent research exploring the relationship between violent extremism and individual psychological variables such as mental disorders, cognitive styles, motivational imbalances, group identity needs, ideological orientations, sensation-seeking behaviors, and group-based emotions, as well as the Big Five and HEXACO models of personality. We further discuss common criticisms against individual differences in approaches to violent extremism. Here, we distinguish between historical disputes, often based on researchers speaking past each other, and challenges in contemporary individual difference research. Having highlighted the significance of individual differences in violent extremism, we focus on how these insights can aid practitioners and shape policies that counteract violent extremism.
“Personality” is considered as a set of individual characteristics and behavioral dispositions based on both temperamental (partially genetic-driven) and developmental (partially culture-driven) components that are relatively stable across time and context. We suggest that these two intertwined components progressively shape autopoietic processes operating at an individual and a social level in accordance with the theory of evolution and its application to human behavior. We discuss existing evidence linking personality traits to the manifestations of personality disorders and diverse forms of psychopathology. Particular attention is dedicated to the evolutionary concept referred to as Life History Theory, considering its utility in predicting the development of personality traits. We also emphasize the need to explore sources of critique and further research, suggesting that a multifaceted approach to the understanding of personality dimensions is crucial.
There remain important questions about how personality shapes risk perceptions, willingness to engage in protective behaviors, and policy preferences during a changing pandemic. Focusing on the Big-5 and COVID-19 attitudes, we find associations between risk perceptions and negative emotionality and agreeableness, as well as between each Big-5 trait and protective behaviors and support for government restrictions. These associations are mostly stable over time, with instability pronounced for lockdown policy support, where agreeableness and conscientiousness diminish in importance as pandemic conditions improve. Negative emotionality, conscientiousness, and agreeableness reduce differences between the political left and right and between those who do and do not trust experts. We highlight the heterogeneous interplay between personality and political ideology to understand pandemic policy support, attitudes, and behaviors.
Describe key elements of adolescent identity development; evaluate the genetic, social, and cultural influences on identity; understand creativity and cultural change as parts of adolescent development.
Environmental changes can be positive in mental illness. Systematic, planned and guided environmental change in all its aspects is called nidotherapy. It has shown some benefit but has not been extended to whole communities.
Aims
A cluster-randomised step-wedge trial is planned in six village communities in Nottinghamshire, England, covering an adult population of 400.
Method
Adults in six villages will be offered a full personal environmental assessment followed by agreed change in different 3-month periods over the course of 1 year. All six villages have populations between 51 and 100 residents and are similar demographically. Assessments of mental health, personality status, social function, quality of life and environment satisfaction will be made. After the initial baseline period of 3 months, two villages will be randomised to nidotherapy for 3 months, a further two at 6 months and the last two at 9 months.
Results
The primary outcome will be change in social function; secondary outcomes include health-related quality of life, anxiety and depressive symptoms, personality status, costs of nidotherapy and life satisfaction. Adverse events will also be recorded. The analysis will be carried out using a multimodal statistical approach examining (a) the change in scores of the primary outcome (social function); (b) change in scores of all secondary outcomes, including costs; and (c) changes in environmental satisfaction.
Conclusions
The findings of this study should help to determine whether nidotherapy has a place in the early detection and treatment of mental pathology.
Chapter 8 focuses on the timescale in which the short-term timescale of activity and experience is embedded, namely, the creative artist’s life course. It discusses artistic talent, art school and training, the artist’s personality, including the relationship between psychopathology and art, the outsider phenomenon, motivation, inspiration, and drives for artistic creation, artistic identities, intersectionality, and the artistic persona, all of which are complex phenomena. The chapter also discusses the complexity of the relationship between personality and artistic creation, based on a complex dynamic systems approach to personality itself.
This study described the development and assessment of the psychometric properties of the Dissociation-Integration of Self-States Scale (D-ISS). This is a new scale to assess dissociation at the ‘between modes’ or self-state (personality) level. The D-ISS is rooted in cognitive behavioural theory and designed to measure between-mode dissociation (dissociation between self-states) in clinical practice and research.
Method:
Study 1: D-ISS scale items were generated and then answered by 344 young adults (16–25 years) who reported experiencing stressful times. An exploratory factor analysis (EFA) was conducted and the results were used to refine the scale to 25 items.
Study 2: The final 25-item D-ISS was completed by 383 adults (18–65 years) who reported experiencing mental health difficulties. A confirmatory factor analysis (CFA) was conducted using the second dataset. Internal consistency, test–retest reliability, convergent validity and divergent validity of the final D-ISS was assessed.
Results:
Study 1: The EFA showed a clear 5-factor solution, which was used to refine the D-ISS to a total of 25 items with five items in each factor.
Study 2: The 5-factor solution from Study 1 was confirmed as a good fit by the CFA using the data collected in Study 2. The D-ISS demonstrated good internal reliability and test–retest reliability. The D-ISS showed no correlations with divergent scales. For convergent validity, the D-ISS showed moderate correlations with the Dissociative Experiences Scale (DES-II).
Conclusions:
The new D-ISS measure of between-mode dissociation is reliable and valid for the population represented by our sample. Further research into its use in clinical populations is required.
Key learning aims
(1) To understand and be able to use a new measure of dissociation at the personality or self-states level.
(2) To understand the cognitive behavioural model of dissociation.
(3) To understand the theoretical underpinnings of the scale, in terms of the effects of childhood and adult adversity and other factors on psychological development.
(4) To consider the potential clinical and research applications of the scale.
(5) To appreciate the limitations of the research so far and the nature of future research required.
We experimentally subliminally prime subjects prior to charity donation decisions by showing words that have connotations of pro-social values for a very brief time (17 ms). Our main finding is that, compared to a baseline condition, the pro-social prime increases donations by approximately 10–17 % among subjects with strong pro-social preferences (universalism values). We find a similar effect when interacting the prime with the Big 5 personality characteristic of agreeableness. We furthermore introduce a novel method for testing for priming, “subliminity”. This method reveals that some subjects are capable of recognizing prime words, and the overall results are weaker when we control for this capacity.
Some of the earliest work on heterogeneity in social preferences focuses on gender differences in behavior. The source of these gender differences is the main interest of this paper. We report on dictator game experiments designed to identify heterogeneity of other-regarding preferences according to personality, gender, status, and whether the choice is framed as giving or taking. We find that the effect of gender on giving is more subtle than previously understood, and is explained collectively by various personality factors. We also find that women, high status treatment individuals, and individuals in the giving language treatment give less, and are also less sensitive to the price of giving.
This chapter of the handbook reviews empirical research on moral character, which has only recently attained a prominent role in psychology, in contrast to long traditions in ethics and education. A person’s moral character comprises their dispositions to think, feel, and act morally, and these dispositions are cross-situationally and temporally fairly consistent. Against a long-standing belief in psychology that the personality disposition of warmth most strongly influences people’s impressions of one another, the evidence suggests that moral character occupies this central position. Moral character exerts its influence on impressions quite independently of other personality traits, and it features prominently in people’s representations of their own personality as well. Moral character is also a central element in a person’s perceived identity – who the person is perceived to be “deep down.” The authors close by charting some of the features from which people infer another’s moral character, including their actions but also, critically, their mental states such as their goals and intentions.