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Umbrella reviews (URs) synthesize findings from multiple systematic reviews on a specific topic. Methodological approaches for analyzing and presenting UR results vary, and reviewers often adapt methods to align with research objectives. This study examined the characteristics of analysis and presentation methods used in healthcare-related URs. A systematic PubMed search identified URs published between 2023 and 2024. Inclusion criteria focused on healthcare URs using systematic reviews as the unit of analysis. A random sample of 100 eligible URs was included. A customized, piloted data extraction form was used to collect bibliographic, conduct, and reporting data independently. Descriptive analysis and narrative synthesis summarized findings. The most common terminology for eligible studies was “umbrella reviews” (65%) or “overviews” (30%). Question frameworks included PICO (43%) and PICOS (14%), with quantitative systematic reviews included in most URs (98%), and 68% including randomized controlled trials. The most frequent methodological guidance source was Cochrane (32%). Data analysis commonly used narrative synthesis and meta-analysis, with Stata, RevMan, and GRADEPro GDT employed for presentation. Information about study overlap and certainty assessment was rarely reported.Variation exists in how data are analyzed and presented in URs, with key elements often omitted. These findings highlight the need for clearer methodological guidance to enhance consistency and reporting in future URs.
Existing guidelines on overviews of reviews and umbrella reviews recommend an assessment of the certainty of evidence, but provide limited guidance on ‘how to’ apply the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to such a complex evidence synthesis. We share our experience of developing a ‘general principles’ approach to applying GRADE to a complex overview of reviews. The approach was developed in an iterative and exploratory manner during the planning and conduct of an overview of reviews of a novel molecular imaging technique for the staging of prostate cancer, involving a formal review by a group of 11 methodologists/health services researchers. This approach was developed during the evidence synthesis process, piloted, and then applied to our ongoing overview of reviews. A ‘general principles’ approach of applying the domains of GRADE to an overview of reviews and arriving at an overall summary judgement for each outcome is presented. Our approach details additional factors to consider, including addressing both the primary study risk of bias as assessed by the included reviews and the risk of bias of the systematic reviews themselves, as well as the statistical heterogeneity observed in meta-analyses conducted within the included reviews. Our approach distilled key principles from the relevant GRADE guidelines and allowed us to apply GRADE to a complex body of evidence in a consistent and transparent way. The approach taken and the methods used to develop our approach may inform researchers working on overviews of reviews, umbrella reviews, or future methodological guidelines.
The only surviving student transcript of any of Kant’s course lectures on political philosophy, the Feyerabend lecture notes of 1784, provide Kant’s criticisms of Natural Law theory as well as a statement of Kant’s own developing theory at a time when he published very little on the topic. This introduction describes the nature of the course lecture and gives an overview of the contributions that follow.
Chapter 1 presents a brief overview of the book and the basics on inpainting, visual perception and Gestalt laws, together with a presentation of the Fitzwilliam Museum dataset of illuminated manuscripts, selected to represent different types of damage and consequent restoration challenges, which will be used throughout the book.
When conducting overviews of reviews, investigators must measure and describe the extent to which included systematic reviews (SRs) contain the same primary studies. The corrected covered area (CCA) quantifies overlap by counting primary studies included across a set of SRs. In this article, we introduce a modification to the CCA, the weighted CCA (wCCA), which accounts for differences in information contributed by primary studies. The wCCA adjusts the original CCA by weighting studies based on the square roots of their sample sizes. By weighting primary studies according to their precision, wCCA provides a useful and complementary representation of overlap in evidence syntheses .
Chapter 10 provides an overview of some of the OT constraints introduced in the book and their rankings. It is shown here that groups of constraints are responsible for parts of the prosodic structure (e.g., the syllable). Some of the constraints introduced in the book play a role at several levels of the hierarchy, especially those regulating the syllable, the foot and the prosodic word.
The Introduction makes the case for why it is important and timely to return afresh to ancient greek epic, despite or even because of the huge amount of scholarship that already exists on this genre. After a brief overview of the current state of the field, it outlines the main points of innovation and interventions of the volume, focusing on its thematic structure, its emphasis on the lesser-known authors or dimensions of Greek epic, and its integration of ancient material and modern responses to it. It ends with a brief overview of the sections of the volume and draws out the connections between the chapters within them.
This introductory chapter, encyclopaedic in nature, covers the main aspects of catastrophe (CAT) risk from a qualitative perspective, offering an overview of what will be explored in quantitative terms in the subsequent chapters. It starts with the definition of the fundamental terms and concepts, such as peril, hazard, risk, uncertainty, probability, and CAT model. It then describes the historical development of catastrophe risk science, which was often influenced by the societal impact of some infamous catastrophes. The main periods are as follows: from ancient myths to medieval texts, mathematization (eighteenth and nineteenth centuries) and computerization (twentieth century). Finally, it provides an exhaustive list of perils categorized by their physical origin, including geophysical, hydrological, meteorological, climatological, biological, extraterrestrial, technological, and socio-economic perils. In total, 42 perils are covered, with historical examples and consequences for people and structures discussed for each one of them.
In this chapter I lay the foundations of the book and give an overview of the argument. After introducing the importance of studying state capacity and the main puzzle of why certain states are set in divergent state building trajectories, I discuss the state of bellicist theory and criticisms related to its alleged functionalist approach to history, and lack of fit with a world where inter-state war has become less frequent. I then turn to Latin America, a poster child of anti-bellicist scholars. There I review the aforementioned books by Centeno, Kurtz, Mahoney, Mazzuca, Saylor, and Soifer, amongst others. My book is set against this new consensus which dismisses war as an explanation for intra-regional variation in state capacity. In a final section, I propose the need to rethink the theory with a focus on the long-term consequences of war outcomes rather than pre-war conditions. The introduction closes with a discussion of my case selection strategy and chapter layout.
Chapter 8 summarizes the book as a whole and discusses theoretical implications. I briefly review the argument and the evidence provided to substantiate its claims. I then assess the implications of these findings for the comparative study of ethnoracial and identity politics and the interdisciplinary study of race in Brazil and Latin America. For comparative political scientists studying ethnic and identity politics, I emphasize how my argument highlights an alternative role for the state in these processes: as a set of actors responsible for shaping citizenship rights and subjective experiences, which in turn shape the subjectivities and identities that citizens bring into the political arena. For interdisciplinary scholars interested in Brazil and Latin America, I emphasize the dynamic nature of the state of racial politics in Brazil, and suggest that future studies move beyond the well-trod characterization of the Brazilian case as the go-to example of the absence of racial politics. I conclude the book with discussion of the challenges ahead for Brazil's racialized democracy.
This chapter provides an introduction to dementia and mild cognitive impairment (MCI). It covers the incidence and prevalence of the most common forms of dementia, and explains the underlying causes in terms of different types of proteinopathy. Risk factors for development of dementia are reviewed, along with protective factors. The role of age is also considered as different subtypes of dementia peak during different age ranges. The contribution of genetics and epigenetics is reviewed, along with the importance of blood supply, sleep, and inflammation. The theory of cognitive and neuronal reserve is introduced as one of the factors which can predict which people are more or less likely to develop dementia and MCI. Connectomics and the arrangement of the brain into circuits is covered, along with developments in neuro-imaging.
Why do states start wars that they ultimately lose? Why do leaders often possess inaccurate expectations of their prospects for victory? The central argument of this book is that institutional variation in how political leaders and bureaucracies relate to one another shapes the propensity for miscalculation at the onset of international conflict. The same institutions that provide the best information also empower the bureaucracy to punish the leader. Thus, miscalculation on the road to war is often the tragic consequence of how leaders resolve the trade-off between good information and political security. This chapter provides an overview of central concepts, briefly summarizes the argument, discusses the contributions of the theory and findings to the field, and details a roadmap of the remainder of the book.
Many states, almost invariably among those most ignored in international relations theory, exhibit some inconsistent and initially incoherent behaviour on the world stage. In particular, some of them have appeared to invite international scrutiny of domestic practices on which their governments rely to stabilize domestic affairs and to stay in power, but for which they could be punished, often by the very state or organization whose attention they request. The introduction provides an overview of the book’s argument and its implications for international relations theory and practice, especially when these states are miscoded as strong supporters of the norms they in fact violate as part of their domestic stabilization. When powerful actors make concessions in order to acquire a success case within their global missions of rights promotion, democratization or good governance reforms, they may also contribute to a slow erosion of those same norms.
This chapter sets the stage for the studies. It presents the outlines of the general framework, gives a brief account of the argument, introduces the gist of the empirical approach, and provides an overview of the volume.
This chapter introduces the context and rationale for the book, noting the increased media and policy focus over the last decade, as well as the broader sociopolitical context of the Covid-19 pandemic, post-Brexit, and post-Trump milieux. The case is made for revisiting and challenging the dominant national frame for understanding academic freedom, noting the internationalisation and massification of higher education globally. The outline of the book is situated as addressing this gap and examining three theoretical and interrelated challenges: i) the presumed dichotomy between freedom and diversity/inclusion, ii) the relative lack of attention to the role of academic freedom in knowledge production, and iii) the lack of recognition of the transnational nature of academic freedom.
Given the fact that in humans the communication of information about emotional states is ubiquitous, people might be forgiven for assuming that pragmatic accounts of linguistic communication would include quite well-developed views of not only the role of emotion in inference, but also how information about emotional states is communicated. However, for a range of reasons, those working in pragmatics have tended to persist with the view that the mental processes behind reason and passions exist in somehow separate domains. As a result, the emotional dimension to linguistic communication has tended to play very much a subordinate role to the rational or cognitive one. Indeed, in many accounts it plays no role at all. This chapter provides an overview of the issues discussed in the book. These all point towards our principal motivation: our belief that emotional or expressive meaning, along with other affect-related, ineffable dimensions of communication, play such a huge role in human interaction that any pragmatic theory worth its salt must account for them.
This chapter serves as a general introduction and overview. It defines the fork in the road and outlines Mozambiques historical context. It goes on to identifying eight key proximate causes and deep factors that determine the basic institutional weaknesses of the country, which are in focus throughout the remainder of the volume.
Several governmental organizations all over the world aim for algorithmic accountability of artificial intelligence systems. However, there are few specific proposals on how exactly to achieve it. This article provides an extensive overview of possible transparency and inspectability mechanisms that contribute to accountability for the technical components of an algorithmic decision-making system. Following the different phases of a generic software development process, we identify and discuss several such mechanisms. For each of them, we give an estimate of the cost with respect to time and money that might be associated with that measure.
Chapter 1 introduces the importance of metaphor to an understanding of time and, in that context, introduces two gaps in our understanding of spatial metaphors for time that the current volume aims to fill.