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This chapter presents Ockham’s theory of demonstration in Summa Logicae III-2, the syllogism that produces scientific knowledge. He relies on Aristotle’s Posterior Analytics and Grosseteste’s commentary it. Grosseteste, however, founded the necessity of demonstration on necessary relations in the world. For Ockham, the main challenge is to elaborate a theory of science that addresses the singular beings in a contingent world. His theory is characterized by a conception of purely logical necessity, a semiotic conception of cause, and the requirement that subject terms must have reference in order for affirmative propositions to be true. Many propositions about the natural world are not susceptible to demonstration in the strict sense, but Ockham distinguishes different kinds of demonstration. He is not so much trying to limit the field of demonstrable natural knowledge as to relax the meaning of demonstrability so that it includes many dubitable propositions that can be made evident.
Trauma plays a critical role in psychosis, but the nature of the relationship between specific symptoms and trauma history remains unclear.
Aims
The aim of the study was to explore the experience of positive symptoms and their association with trauma and life events from the perspective of patients with first-episode psychosis (FEP).
Method
Seventeen participants who were enrolled in an FEP programme participated in a qualitative interview examining their life and trauma events, the onset of their symptoms, their experience of positive symptoms and their perceived associations between symptoms and life and trauma events. The interview was based on a semi-structured interview of six main questions and follow-up questions. Participants also completed the Trauma and Life Experiences Checklist (TALE), and were asked about the relevance of the whole interview. Thematic content analysis, exploratory cluster analysis and matrix queries coding were performed.
Results
Fifteen participants described the experience of psychotic symptoms as distressing or traumatic. Eleven participants attributed the onset of positive psychotic symptoms to trauma and life events. Ten participants described explicit thematic associations between their symptoms and trauma and life events. Twelve participants evaluated the interview as relevant and helpful.
Conclusions
Our findings give insight into the lived experience of positive symptoms and potential psychological interventions valuing causal theories of participants and the association with life and trauma events.
Chapter 4 explores the normative challenge of the experience of dehumanisation. It starts from a paradigmatic case of dehumanisation, as it was described from a first-person perspective: the torture of Jean Améry. This description offers a phenomenology of dehumanisation. In order to deepen the analysis, the experience of dehumanisation is subsequently confronted with recent work on alienation. This opens up the critical potential of the experience of dehumanisation challenging important concepts that figure prominently in debates on (the aftermath of) atrocities.
Clozapine is the only licensed medication for treatment-resistant schizophrenia, although it is underused. Healthcare professionals (medical and non-medical professionals) play a crucial role in the management of clozapine. Consultant psychiatrists are accountable for the initiation of clozapine, whereas non-medical professionals are often responsible for the monitoring, the management of side effects and patient education. It appears that healthcare professionals‘ (HCPs) competence and confidence may have an effect on clozapine underutilisation.
Aim:
To synthesise the most pertinent literature examining the factors influencing HCPs competence and confidence in the management of clozapine and how these factors influence variation in prescribing practice.
Methods:
A review of the literature focusing on these elements was conducted. The Population, Context, Outcome (PCO) framework was adopted to support the literature search. The databases Medline, Psychinfo, Scopus, Cinahl, Pubmed, Embase, British Library, Ethos e-thesis, Google Scholar, Dart Europe e-thesis were consulted; the search was completed in January 2025. Screening, selection, data extraction and quality assessment were conducted independently by two researchers. Thematic analysis was used to investigate and compare the data emerging from the studies.
Results:
Thirty-four articles were included in the review. Six themes were identified: attitude toward and knowledge about clozapine, misconceptions (regarding side effects, monitoring and co-morbidities), guidelines, education, training and experience. HCPs self-reported as competent with guidelines (local and national), yet they expressed less confidence in their ability to adhere to them and were uncertain about managing side effects. Lack of education, training and insufficient exposure to clozapine management were significant factors impacting competence and confidence, resulting in clozapine underuse and variance in prescribing practice. The review highlighted a gap in the literature, as only a few studies involving non-medical professionals were found.
Conclusions:
A general lack of education and training related to clozapine use was identified amongst all professionals.
The impact of educational programmes on improving competence and enhancing confidence was considered positive, however when integrated with clinical practice.
The studies identified in this review were lacking in the involvement of non-medical professionals. Given their crucial role in managing side effects and educating patients and carers, it is evident that their inclusion in future research is imperative.
Ketamine exerts potent but transient antidepressant effects in treatment-resistant depression (TRD). Combinations of ketamine and psychotherapy have attracted interest, but no trial has investigated a psychedelic model of ketamine–psychotherapy for TRD to our knowledge.
Aims
This secondary analysis of a randomised clinical trial (RCT) explores the therapeutic effects and experiential mechanisms of the Montreal Model of ketamine–psychotherapy for TRD, with or without music.
Method
A two-centre, single-blinded, RCT conducted in Montreal, Canada, between January 2021 and August 2022 (NCT04701866). Participants received ketamine–psychotherapy for TRD – six subanaesthetic infusions over 4 weeks and psychological support – with either music or matched non-music support during ketamine doses, as per random group assignments. The primary therapeutic outcome was the Montgomery–Åsberg Depression Rating Scale, assessed by blinded raters. Psychedelic-like experiences, evaluated by the Mystical Experience Questionnaire and Emotional Breakthrough Inventory, and their session-by-session relationships with depression were explored with multilevel, time-lagged covariate models with autoregressive residuals.
Results
Thirty-two participants with severe and highly comorbid TRD, including high rates of personality disorder and suicidality, received 181 ketamine infusions. Therapeutic outcomes and psychedelic experiences did not differ between music (n = 15) and non-music (n = 17) interventions. Both groups experienced significant reductions in clinician-rated and self-reported depression (d = 1.2 and d = 0.87, respectively; p < 0.001), anxiety (d = 0.8, p < 0.001) and suicidality (d = 0.4, p < 0.05) at 4 weeks, fully maintained at 8-week follow-up. Ketamine experiences were highly emotional and mystical. Converging analyses supported mystical-like ketamine experiences as mechanisms of its antidepressant effects.
Conclusions
This trial found large and notably sustained benefits of ketamine–psychotherapy for severe TRD, with or without music, and psychedelic experiences of comparable intensity to those observed with psilocybin. Mystical-like experiences may particularly contribute to ketamine’s immediate and persistent psychiatric benefits.
Heidegger on Transcendence maps the deep ambivalences that attend Heidegger's lasting commitment to the transcendental tradition, construed here broadly to include not only phenomenological but also modern, medieval, and ancient predecessors. It defends Heidegger's commitment by explicating the essential function of the transcendental within his path of thinking and by contextualizing his later comments on transcending the limits of the subject still inherent in the metaphysical language heretofore available to transcendental thought.
Not all eighteenth-century mock-arts were satires. The long, mixed blank-verse poems modelled on Virgil’s Georgics that were popular throughout the period always dealt positively with the practical, mechanical world. Georgic poems followed oblique strategies, coded into the genre by their ancient models: their paradoxically rational appeal to slow, unconscious experience and their characteristic swerves into digressive anecdote, haptic description and mythography. Georgic (like satire) is interested in the processes by which people sharpen their wits, not through the exercise of raillery, but through the ‘labor improbus’ of skilled work. Like the Scriblerian mock artists, Georgic writers applied representations of the mechanical arts to political contexts. Comparison between satirical mock arts and georgic poems is fruitful because of what they have in common: a rhetoric of indirection, a psychology focused on extended cognition and tacit knowledge and a fascination with the mechanics of commercial production.
We report on sealed-bid second-price auctions that we conducted on the Internet using subjects with substantial prior experience: they were highly experienced participants in eBay auctions. Unlike the novice bidders in previous (laboratory) experiments, the experienced bidders exhibited no greater tendency to overbid than to underbid. However, even subjects with substantial prior experience tended not to bid their values, suggesting that the non-optimal bidding of novice subjects is robust to substantial experience in non-experimental auctions. We found that auction revenue was not significantly different from the expected revenue the auction would generate if bidders bid their values. Auction efficiency, as measured by the percentage of surplus captured, was substantially lower in our SPAs than in previous laboratory experiments.
This study investigates whether market composition affects individual bidding and the aggregate market in first-price sealed-bid common-value auctions. It compares all-inexperienced markets with only inexperienced bidders, all-experienced markets with only experienced bidders, and mixed markets with both types. On average, there is no market-composition effect for both experienced and inexperienced bidders. When controlling for gender, a market-composition effect appears for inexperienced subjects: Men bid more aggressively in mixed than in all-inexperienced markets, and women bid more aggressively in all-inexperienced markets. On the aggregate level, the all-inexperienced market is the most aggressive with highest winning bids; the all-experienced market is the least aggressive. The mixed market is in between: Both experienced and inexperienced win auctions in this market, but experienced bidders win less auctions than they should.
We run laboratory experiments to analyze the impact of prior investment experience on price efficiency in asset markets. Before subjects enter the asset market they gain either no, positive, or negative investment experience in an investment game. To get a comprehensive picture about the role of experience we implement two asset market designs. One is prone to inefficient pricing, exhibiting bubble and crash patterns, while the other exhibits efficient pricing. We find that (i) both, positive and negative, experience gained in the investment game lead to efficient pricing in both market settings. Further, we show that (ii) the experience effect dominates potential effects triggered by positive and negative sentiment generated by the investment game. We conjecture that experiencing changing price paths in the investment game can create a higher sensibility on changing fundamentals (through higher salience) among subjects in the subsequently run asset market.
This essay argues that what distinguishes a negatively valenced phenomenal experience from suffering is an ability to make meaning of the experience. In this sense, intellectual ability influences the extent and nature of suffering. But this connection is not a straightforward one, since intellectual ability cuts both ways. On the one hand, those with higher levels of intellectual functioning are better able to make meaning of negative experiences, thereby reducing their suffering. On the other, intellectual ability can influence the depth and breadth of one’s negative experiences, thereby increasing suffering. This means that we cannot make any assumptions about a person’s susceptibility to suffering based on their level of intellectual functioning alone.
This chapter explores the political significance of experience. Imperial authorities and political writers deemed experience as one of the major attributes of a good ruler, and imperial officials acquired it thanks to their mobility and by serving in different places across the world. By integrating the study of the political theory with the actual practices of the officials, the chapter reveals how officials’ expertise was gained, valued, and transferred across the different imperial locations – not only from Europe to America but also the other way around. Officials’ experience, which was logged in their informaciones de méritos y servicios, spawned a new epistemological milieu that privileged direct knowledge and sensorial experimentation.
This chapter of the handbook discusses the role of mind perception in the categorization of individuals as moral agents and moral patients. Moral agents are defined as individuals that can commit morally wrong actions; moral patients are defined as individuals that can be morally wronged. It is generally agreed that the attribution of moral agency and moral patiency is linked to the attribution of mental capacities and traits. The chapter surveys a variety of models of mind perception, some of which focus on the representation of mental capacities, some of which focus on the representation of mental traits. The dominant model of mind perception in moral psychology is the experience-agency model, which divides the space of mindedness into experiential capacities like sentience and self-awareness, and agentic capacities like deliberative reasoning and self-control. Reviewing the empirical literature on moral categorization, the author argues that neither the experience-agency model nor any of the major alternatives to it captures all the factors to which everyday attributions of moral agency and moral patiency are sensitive.
“Ars” came to be laden with specific meaning in the intellectual culture of late-Republican Rome, with some artes being regarded as intellectually and socially worthier than others. These “higher artes” were distinguished by several features that would form the premises for the scientific culture of the artes in the early Roman Empire. These premises were established in Rome by the reception of Greek notions of technê (τέχνη) but were elaborated independently and joined for the first time into a unified conception of specialized knowledge by Roman thinkers, including Cicero and Varro. The higher artes are logically organized and systematically presented, hence systematic. They are related to one another in their principles and methods, hence interdisciplinary. They entail explanatory knowledge of their methods in terms of causes in nature, and are hence explanatory. And they balance experience and practical know-how with theoretical knowledge, and are hence balanced.
Of Celsus’ Artes (early first century AD), which originally handled agriculture, medicine, the art of war, rhetoric, and philosophy, only the eight books on medicine survive. Celsus’ work attests to the vibrant interdisciplinary culture of the early Imperial artes. The books De medicina in particular reveal a distinctive conceptualization of specialized knowledge that bears the hallmarks of the scientific culture of the artes but contrasts sharply with the approaches of Vitruvius and Columella. Celsus’ theory of the medical ars self-consciously appropriates but also develops and expands key methodological terms from the Greek medical tradition, including reason, experience, cause, and nature. These terms set the parameters for Celsus’ exposition of medicine, as exemplified in discussions of bloodletting, fevers, and fractures. Celsus’ more reserved attitude toward the kind of knowledge of nature required for expertise does not ignore the central preoccupations of the scientific culture of the artes, but instead pragmatically inflects them for medical practice.
Leaders play a central role in world politics, and threat perception is a crucial element in the study and practice of International Relations (IR). Yet existing accounts of how leaders perceive threats are inadequate, drawing on an incomplete notion of leaders as (ir)rational information processors that pays no attention to the leader’s experience of danger as it unfolds in time and how such experience is structured. By integrating a framework developed by linguist Ray Jackendoff to describe the experience of language with the study of danger in International Relations, and by employing an interpretive textual analysis technique to danger descriptions made by world leaders embedded in different historical and cultural settings constructing different security dangers, I develop and illustrate the ‘danger framework’. In describing the unique features with which leaders experience security dangers, the danger framework theorises the qualia of danger experience and how it is organised into the conscious field of leaders. In doing so, the paper makes progress on three problems for existing accounts of threat perception in IR, illuminates important research puzzles, and provides the literature on experience and Ontological Security Studies (OSS) with micro-foundations.
We report experiments investigating how experience influences the endowment effect. Our experiments feature endowments which are bundles of unfamiliar consumption goods. We examine how a subject’s willingness to swap items from their endowment is influenced by prior experiences of tasting the goods in question and by prior experiences of choosing between them. We do not find a statistically significant endowment effect in our baseline treatment and, because of this, we are unable to test for an effect of consumption experience. We do find an endowment effect when the endowment is acquired in two instalments and, in this setting, we find some evidence that choice experience increases trading. In a follow-up experiment, we find evidence that the absence of an endowment effect in our baseline treatment is due to subjects being more willing to swap when they do not have to give up the last unit of their endowment.
This study aimed to explore healthcare experiences of rural-living patients both with (attached) and without (unattached) a local primary care provider.
Background:
Primary care providers serve a gatekeeping role in the Canadian healthcare system as the first contact for receiving many health services. With the shortage of primary care providers, especially in rural areas, there is a need to explore attached and unattached patient experiences when accessing healthcare.
Methods:
A cross-sectional survey of rural patients both with (attached) and without (unattached) a primary care provider was conducted July–September 2022. An open-ended question gathered participants’ thoughts and experiences with provider shortages.
Findings:
Overall, 523 (Mean age = 51 years, 75% female) rural British Columbia community members (306 attached; 217 unattached) completed the survey. Despite similar overall health, unattached patients received care less frequently overall compared to attached patients, including less frequent non-urgent and preventive care. The vast majority of attached patients sought care from a regular provider whereas unattached patients were more likely to use walk-in, emergency department, and urgent care and 29% did not seek care at all. Overall, 460 (88.0%) provided a response to the open-ended doctor shortage question. Similar themes were found among both attached and unattached participants and included: i) the ubiquity of the doctor shortage, ii) the precariousness or fluidity of attachment status, and iii) solutions and recommendations. Greater attention is needed on the negative and cyclical impacts provider shortages have for both attached and unattached patients alike.
Hegel’s Philosophy of Nature is integrated into the fabric of his system. We absorb into our thinking the concepts and relationships that have survived the successes and failures of experience (Phenomenology). Through disciplined thought we articulate the internal logic of those concepts (Logic). By working out what the world beyond thought would be like, seeing how the world instantiates those expectations, and then building those discoveries into our next ventures, we develop a systematic picture of the stages of natural complexity and human functioning (Philosophies of Nature and Spirit). Since Hegel’s time, however, we have discovered that nature has a history; time and space are no longer absolutes; the discoveries of science have expanded in both breadth and detail; and our comprehensive explanations for the way the world functions are continually being falsified by the discovery of new facts. A philosophy of nature, then, needs to reshape the way reason functions. Adopting the strategies we use to solve problems and that science uses to develop and test hypotheses, we broaden our perspective to cover multiple domains in nature and search for patterns that show how and why they fit together as they do.
This chapter examines forms of self-writing (memoir, autobiography, diaries, documentary prose, and other in-between genres) that demonstrate an ‘orientation toward authenticity’, to borrow the phrase of the writer-scholar Lidiia Ginzburg. The arc spans the late seventeenth century to the present, with a focus on the period from the end of World War II to the late Soviet era, which witnessed an explosion of non-fictional narratives to document the war, camps, and Stalinist terror. The chapter takes its cues from Ginzburg’s theory that in-between prose is uniquely innovative when it fixes its attention on concepts of the self and literary forms, and that it flourishes most when canonical genres are in flux. In addition to the topic of childhood and, more centrally, personal encounters with history, the chapter discusses the role of women writers, and the sub-genre of the memoirs of contemporaries written by members of the intelligentsia.