A structurally transforming multi-mode product can realize a changing set of functions across its modes, replacing multiple related products while offering increased cost, space, and time efficiency. However, there is a lack of connected methods that address the additional design complexities due to the product’s physical transformations and the resulting structural component-sharing between modes. A framework, grounded in standard design practice and built upon existing methods, is proposed to help navigate the two most impacted design stages: 1. Problem Definition and 2. Conceptual Design. The Problem Definition stage in this new framework involves identifying the external factor that determines the product’s modes and defining the functional requirements for the modes and transformation methods. The Conceptual Design stage involves iteratively linking conceptualized forms of each mode to adjacent modes through conceptualized transformation methods. The framework is demonstrated in a case study involving the design of a structurally transforming multi-mode piece of children’s furniture that transforms between a cradle, floor seat and a multipurpose toddler step stool. The proposed framework is a promising step toward systematically, cohesively, and comprehensively addressing design challenges during the development of a wide variety of structurally transforming multi-mode products, therefore facilitating better, more effective product design.