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Tics are brief, sudden, non-rhythmic, repetitive movements. Tics can be motor or vocal. Further, both motor and vocal tics can be either simple or complex. Simple tics typically involve only one group of muscles and are brief and meaningless, whereas complex tics may last longer and appear more purposeful. Tic disorders usually begin in childhood and are classified according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) into four groups: (1) provisional tic disorder, (2) chronic motor or vocal tic disorder, (3) Tourette disorder (or Gilles de la Tourette syndrome), (4) tic disorder not otherwise specified. As tics can resemble almost any other movement disorder, phenotypic analysis alone is insufficient and patients must be questioned whether the execution is preceded by a premonitory sensation (urge to do, urge to move) and whether a temporary control of the movement can be achieved. Also, relief following execution of the tic is frequently reported. There are no biomarkers available for tics and diagnosis therefore remains strictly clinical.
This chapter covers generalized anxiety disorder, panic disorder, specific phobia, social anxiety disorder, agoraphobia, separation anxiety disorder, and selective mutism. Based on a review using the new criteria for empirically supported treatments, there is strong research support for: (a) exposure therapies for specific phobias, (b) cognitive and behavioral therapies for generalized anxiety disorder, (c) cognitive-behavioral therapy for panic disorder, and (d) cognitive-behavioral therapy for social anxiety disorder. The two primary components of treatment include exposure and addressing cognitive biases. Each of these components is broken down into additional parts. A sidebar also discusses acceptance and commitment therapy.
Autism spectrum disorder and intellectual developmental disorder are often comorbidly diagnosed, but many adults meet criteria for just one of these disorders. Broad approaches include applied behavior analysis, cognitive-behavioral therapy, mindfulness based therapy, social skills interventions, and employment-related interventions. A sidebar discusses co-occurring mental health conditions.
Using the new criteria for empirically supported treatments, cognitive-behavioral therapy and contingency management were both given strong recommendations for substance use disorders. Credible components of treatment include skills training, motivational enhancement, and access to nondrug alternative reinforcement. A sidebar discusses mutual support organizations such as Alcoholics Anonymous. Another sidebar describes harm reduction strategies.
Eating disorders include anorexia nervosa, bulimia nervosa, and binge eating disorder. The treatments with the most research support are cognitive-behavioral therapy, interpersonal psychotherapy, and family based treatment. Credible components of treatment include psychoeducational strategies, nutritional/dietary strategies, exposure therapy, social support, in-session weighing, cognitive strategies, and relapse prevention. A sidebar describes body checking and body avoidance.
The primary focus of this chapter is chronic pain. Treatment approaches discussed include cognitive-behavioral therapy and acceptance and commitment therapy. Credible components of treatment include behavioral goals, exposure, activity pacing, cognitive skills training, acceptance, relaxation, mindfulness, and psychological flexibility. A sidebar describes somatic symptom disorder.
Broad approaches to treating attention-deficit/hyperactivity disorder in adults include cognitive-behavioral therapy and dialectical behavior therapy. Credible components of treatment include an emphasis in learning theory, time estimation, temporal discounting, prioritizing/planning, self-instruction, cognitive refraining, and mindfulness. A sidebar discusses co-occurring conditions such as anxiety and depression.
Current clinical practice guidelines highlight several treatment approaches for depressive disorders, including acceptance and commitment therapy, behavior therapy, cognitive-behavioral therapy, interpersonal psychotherapy, and short-term psychodynamic psychotherapy. Credible components of treatment include behavioral activation, cognitive restructuring, problem solving, mindfulness, and a focus on interpersonal targets. The chapter also includes a sidebar on the importance of cultural humility.
This chapter discusses schizophrenia and other psychosis spectrum disorders. Treatment approaches include cognitive-behavioral therapy, assertive community treatment, family therapy, social learning/token economy programs, supported employment, cognitive remediation, and peer support. Credible components of treatment include psychoeducation, skill acquisition, emotional regulation strategies, interpersonal support, and care coordination. A sidebar highlights the importance of common factors such as empathy.
Dissociative disorders encompass depersonalization, derealization, dissociative amnesia, dissociative identity disorder, and other diagnostic classifications. The treatment literature for dissociative disorders is limited. Some emerging and promising treatments include phase-oriented treatment, cognitive-behavioral therapy, dialectical behavior therapy, schema therapy, the Unified Protocol, and the Treatment of Patients with the Dissociative Disorders Network Program. A sidebar provides recommendations for future research; another sidebar discusses access to treatment.
The most efficacious treatments for bipolar disorder include cognitive-behavioral therapy, family-focused therapy, and systemic care. Credible components of treatment include psychoeducation, cognitive restructuring, social support, and relapse prevention. The chapter also include a sidebar on research therapists and another on overcoming challenges to learning and implementing therapy.
Dialectical behavior therapy (DBT) is a specialized treatment that has a growing evidence base for binge-spectrum eating disorders. However, cost and workforce capacity limit wide-scale uptake of DBT since it involves over 20 in-person sessions with a trained professional (and six sessions for guided self-help format). Interventions translated for delivery through modern technology offer a solution to increase the accessibility of evidence-based treatments. We developed the first DBT-specific skills training smartphone application (Resilience: eDBT) for binge-spectrum eating disorders and evaluated its efficacy in a randomized clinical trial.
Method
Participants reporting recurrent binge eating were randomized to Resilience (n = 287) or a waitlist (n = 289). Primary outcomes were objective binge eating episodes and global levels of eating disorder psychopathology. Secondary outcomes were behavioral and cognitive symptoms, psychological distress, and the hypothesized processes of change (mindfulness, emotion regulation, and distress tolerance).
Results
Intention-to-treat analyses showed that the intervention group reported greater reductions in objective binge eating episodes (incidence rate ratio = 0.69) and eating disorder psychopathology (d = −0.68) than the waitlist at 6 weeks. Significant group differences favoring the intervention group were also observed on secondary outcomes, except for subjective binge eating, psychological distress, and distress tolerance. Primary symptoms showed further improvements from 6 to 12 weeks. However, dropout rate was high (48%) among the intervention group, and engagement decreased over the study period.
Conclusion
A novel, low-intensity DBT skills training app can effectively reduce symptoms of eating disorders. Scalable apps like these may increase the accessibility of evidence-based treatments.
Self-guided Internet-based cognitive behavior therapy (iCBT) for migraine interventions could improve access to care, but there is poor evidence of their efficacy.
Methods:
A three-arm randomized controlled trial compared: iCBT focused on psychoeducation, self-monitoring and skills training (SPHERE), iCBT focused on identifying and managing personal headache triggers (PRISM) and a waitlist control. The primary treatment outcome was a ≥ 50% reduction in monthly headache days at 4 months post-randomization.
Results:
428 participants were randomized (mean age = 30.1). 240 participants (56.2%) provided outcome data at 4 months. Intention-to-treat (ITT) analysis with missing data imputed demonstrated that the proportion of responders with a ≥ 50% reduction was similar between combined iCBTs and waitlist (48.5/285, 17% vs. 16.6/143, 11.6%, p = 0.20), but analysis of completers showed both iCBT programs to be superior to the waitlist (24/108, 22.2% vs. 13/113, 11.5%, p = 0.047). ITT analysis with missing data imputed showed no difference between the two iCBTs (SPHERE: 24.8/143, 17.3% vs. PRISM: 23.7/142, 16.7%, p = 0.99). Uptake rates of the iCBTs were high (76.9% and 81.69% logged in at least once into SPHERE and PRISM, respectively), but adherence was low (out of those who logged in at least once, 19.01% [21/110] completed at least 50% modules in SPHERE and 7.76% [9/116] set a goal for trying out a given trigger-specific recommendation in PRISM). Acceptability ratings were intermediate.
Conclusions:
Self-guided iCBTs were not found to be superior in our primary ITT analysis. Low adherence could explain the lack of effects as completer analysis showed effects for both interventions. Enhancement of adherence should be a focus of future research.
Controlled research examining maintenance treatments for responders to acute interventions for binge-eating disorder (BED) is limited. This study tested efficacy of lisdexamfetamine (LDX) maintenance treatment amongst acute responders.
Methods
This prospective randomized double-blind placebo-controlled single-site trial, conducted March 2019 to September 2023, tested LDX as maintenance treatment for responders to acute treatments with LDX-alone or with cognitive-behavioral therapy (CBT + LDX) for BED with obesity. Sixty-one (83.6% women, mean age 44.3, mean BMI 36.1 kg/m2) acute responders were randomized to LDX (N = 32) or placebo (N = 29) for 12 weeks; 95.1% completed posttreatment assessments. Mixed-models and generalized-estimating equations comparing maintenance LDX v. placebo included main/interactive effects of acute (LDX or CBT + LDX) treatments to examine their predictive/moderating effects.
Results
Relapse rates (to diagnosis-level binge-eating frequency) following maintenance treatments were 10.0% (N = 3/30) for LDX and 17.9% (N = 5/28) for placebo; intention-to-treat binge-eating remission rates were 59.4% (N = 19/32) and 65.5% (N = 19/29), respectively. Maintenance LDX and placebo did not differ significantly in binge-eating but differed in weight-loss and eating-disorder psychopathology. Maintenance LDX was associated with significant weight-loss (−2.3%) whereas placebo had significant weight-gain (+2.2%); LDX and placebo differed significantly in weight-change throughout treatment and at posttreatment. Eating-disorder psychopathology remained unchanged with LDX but increased significantly with placebo. Acute treatments did not significantly predict/moderate maintenance-treatment outcomes.
Conclusions
Adults with BED/obesity who respond to acute lisdexamfetamine treatment (regardless of additionally receiving CBT) had good maintenance during subsequent 12-weeks. Maintenance lisdexamfetamine, relative to placebo, did not provide further benefit for binge-eating but was associated with significantly better eating-disorder psychopathology outcomes and greater weight-loss.
Little is known about the effectiveness of cognitive behavioral therapy (CBT) specific self-help for psychosis, given that CBT is a highly recommended treatment for psychosis. Thus, research has grown regarding CBT-specific self-help for psychosis, warranting an overall review of the literature. A systematic literature review was conducted, following a published protocol which can be found at: https://www.crd.york.ac.uk/prospero/export_record_pdf.php. A search was conducted across Scopus, PubMed, PsycInfo, and Web of Science to identify relevant literature, exploring CBT-based self-help interventions for individuals experiencing psychosis. The PICO search strategy tool was used to generate search terms. A narrative synthesis was conducted of all papers, and papers were appraised for quality. Ten studies were included in the review. Seven papers found credible evidence to support the effectiveness of CBT-based self-help in reducing features of psychosis. Across the studies, common secondary outcomes included depression, overall psychological well-being, and daily functioning, all of which were also found to significantly improve following self-help intervention, as well as evidence to support its secondary benefit for depression, anxiety, overall well-being, and functioning. Due to methodological shortcomings, long-term outcomes are unclear.
Eating disorders (EDs) can be treated with inpatient, residential, partial hospital, and outpatient care through various therapeutic orientations. Studies indicate that evidence-based treatment models in the least restrictive environment lead to the best outcomes. One treatment option is FBT for adolescent EDs, which encourages families to externalize the illness and be a primary agent of change. Cognitive-behavioral therapy (CBT) for EDs is collaborative and requires patient motivation. It includes forms like CBT-E, CBT-guided self-help, 10-session cognitive-behavioral therapy, and CBT for ARFID which are structured and manualized. CBT-E targets body weight, shape, and control and maintenance variables of the illness. Interpersonal psychotherapy (IPT) is a structured, time-limited treatment for adults with BN and BED, focusing on how relationships affect ED symptoms. Both IPT and CBT are effective for binge-related behaviors and cognitions. CBT-AR is a treatment option for individuals over 10 years old with all presentations of ARFID who are medically stable and not dependent on tube feeding.
The post-COVID-19 condition describes the persistence or onset of somatic symptoms (e.g. fatigue) after acute COVID-19. Based on an existing cognitive-behavioral treatment protocol, we developed a specialized group intervention for individuals with post-COVID-19 condition. The present study examines the feasibility, acceptance, and effectiveness of the program for inpatients in a neurological rehabilitation setting.
Methods
The treatment program comprises eight sessions and includes psychoeducational and experience-based interventions on common psychophysiological mechanisms of persistent somatic symptoms. A feasibility trial was conducted using a one-group design in a naturalistic setting. N = 64 inpatients with a history of mild COVID-19 that fulfilled WHO criteria for post-COVID-19 condition were enrolled. After each session, evaluation forms were completed and psychometric questionnaires on somatic and psychopathological symptom burden were collected pre- and post-intervention.
Results
The treatment program was well received by participants and therapists. Each session was rated as comprehensible and overall satisfaction with the sessions was high. Pre-post effect sizes (of standard rehabilitation incl. new treatment program; intention-to-treat) showed significantly reduced subjective fatigue (p < 0.05, dav = 0.33) and improved disease coping (ps < 0.05, dav = 0.33–0.49).
Conclusions
Our results support the feasibility and acceptance of the newly developed cognitive-behavioral group intervention for individuals with post-COVID-19 condition. Yet, findings have to be interpreted cautiously due to the lack of a control group and follow-up measurement, the small sample size, and a relatively high drop-out rate.
This chapter describes pseudoscience and questionable ideas related to psychosis and the schizophrenia spectrum. The chapter opens by discussing diagnostic confusion and questionable assessment practices such as projective tests. The chapter also considers myths that influence treatment. Dubious treatments include homeopathy, psychoanalysis, vitamin therapy, lobotomy, insulin coma therapy, and exorcism. The chapter closes by reviewing research-supported approaches.
This chapter describes pseudoscience and questionable ideas related to bipolar disorder I, bipolar disorder II, cyclothymic disorder, as well as mania and other related mood states. The chapter opens by discussing myths such as the idea that people on the bipolar spectrum want to be impaired. Several controversies related to treatment are also discussed, such as misleading products. The chapter closes by reviewing research-supported approaches.
This chapter describes pseudoscience and questionable ideas related to somatic symptoms. The chapter opens by discussing the challenge inherent in measuring treatment gains in subjectively reported symptoms. Dubious treatments discussed include acupuncture, hypnosis, homeopathy, herbal remedies, cannabidiol products, dietary supplements, and medical devices (e.g., mystical patches). The chapter closes by reviewing research-supported approaches.