In 2012, at age 64, Anne desired to retire. She didn’t want to serve past her prime. If she retired, her lab space could go instead to a young investigator just starting a career. Anne was pleased with the search committee’s replacement – Merit Cudkowicz – a woman on Anne’s faculty who had established and directed their Program in Clinical Investigation. Her area of expertise was amyotrophic lateral sclerosis (ALS). She had also come down to Venezuela one year to work on the project. She went from ‘bench to bedside’ by assessing potential new therapies discovered at the laboratory bench in humans using the best clinical trial designs. To celebrate completing 21 years of service, Anne organized a trip to the Galapagos. She found an outfit with a boat and invited 20 of her best friends to go on the trip, including Nancy, her sister Alice, David Housman and his wife, Gill Bates and her husband, Alice Flaherty and her family, Anne’s daughter Ellen and her boyfriend and others. Anne became chair of the Scientific Advisory Board of Nancy’s HDF, which entailed assigning grant reviewers, reviewing grants and running meetings. She was appointed chair of the Scientific Advisory Board of the Collaborative Center for XDP.

Abstract: After Jack’s death, it took Anne time to get back into any routine at work. Because she was in a lot of pain, Anne wasn’t on call for patient care for the first year after Jack was gone. She fell into a deep depression from her grief but tried her best to function. Anne’s colleagues and friends such as Beverly Mahfuz, Walter Koroshetz, Jane Holtz, Sherri O’Grady and Rita Zollo (Jack’s secretary) all pitched in. Anne also turned to alcohol to ease her pain. She didn’t recognize that she had a problem with alcohol. Alice Flaherty, Anne’s colleague and trainee, helped her find a psychiatrist. Anne went to work every day and completed all her administrative work. There was a lot to do planning the new building – meeting with the architects and construction crews. Anne’s daughters managed at school despite their grief. Anne held a memorial in honor of Jack at a church. People came from the hospital and laboratory. Friends and family were there. Jack’s patients came. Neurologists from all over the country came. The next day, Anne took the urn of ashes with Jack’s dad, his wife, Jack’s sister and brother and their spouses, Ellen and Jessie, Jang-Ho and his wife and Nancy Serrell up to the graveyard in New Hampshire to say their goodbyes and put notes in the urn.