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Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study

Published online by Cambridge University Press:  20 September 2017

J. Glaus ,
R. von Känel ,
A. M. Lasserre ,
M.-P. F. Strippoli ,
C. L. Vandeleur ,
E. Castelao ,
M. Gholam-Rezaee ,
C. Marangoni ,
E.-Y. N. Wagner  and
P. Marques-Vidal
...Show all authors
J. Glaus*
Affiliation:
Department of Psychiatry, Psychiatric Epidemiology and Psychopathology Research Center, Lausanne University Hospital, Lausanne, Switzerland Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
R. von Känel
Affiliation:
Department of Psychosomatic Medicine, Clinic Barmelweid, Barmelweid, Switzerland Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
A. M. Lasserre
Affiliation:
Department of Psychiatry, Psychiatric Epidemiology and Psychopathology Research Center, Lausanne University Hospital, Lausanne, Switzerland
M.-P. F. Strippoli
Affiliation:
Department of Psychiatry, Psychiatric Epidemiology and Psychopathology Research Center, Lausanne University Hospital, Lausanne, Switzerland
C. L. Vandeleur
Affiliation:
Department of Psychiatry, Psychiatric Epidemiology and Psychopathology Research Center, Lausanne University Hospital, Lausanne, Switzerland
E. Castelao
Affiliation:
Department of Psychiatry, Psychiatric Epidemiology and Psychopathology Research Center, Lausanne University Hospital, Lausanne, Switzerland
M. Gholam-Rezaee
Affiliation:
Department of Psychiatry, Psychiatric Epidemiology and Psychopathology Research Center, Lausanne University Hospital, Lausanne, Switzerland
C. Marangoni
Affiliation:
Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
E.-Y. N. Wagner
Affiliation:
Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
P. Marques-Vidal
Affiliation:
Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
G. Waeber
Affiliation:
Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
P. Vollenweider
Affiliation:
Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
M. Preisig
Affiliation:
Department of Psychiatry, Psychiatric Epidemiology and Psychopathology Research Center, Lausanne University Hospital, Lausanne, Switzerland
K. R. Merikangas
Affiliation:
Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
*
*Address for correspondence: J. Glaus, Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, 35 Convent Drive, MSC 3720, Bldg 35A, Room 2E422A, Bethesda, MD 20892, USA. (Email: jennifer.glaus@nih.gov)
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Abstract

Background

There has been increasing evidence that chronic low-grade inflammation is associated with mood disorders. However, the findings have been inconsistent because of heterogeneity across studies and methodological limitations. Our aim is to prospectively evaluate the bi-directional associations between inflammatory markers including interleukin (IL)-6, tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hsCRP) with mood disorders.

Methods

The sample consisted of 3118 participants (53.7% women; mean age: 51.0, s.d. 8.8 years), randomly selected from the general population, who underwent comprehensive somatic and psychiatric evaluations at baseline and follow-up (mean follow-up duration = 5.5 years, s.d. 0.6). Current and remitted mood disorders including bipolar and major depressive disorders (MDD) and its subtypes (atypical, melancholic, combined atypical and melancholic, and unspecified) were based on semi-structured diagnostic interviews. Inflammatory biomarkers were analyzed in fasting blood samples. Associations were tested by multiple linear and logistic regression models.

Results

Current combined MDD [β = 0.29, 95% confidence interval (CI) 0.03–0.55] and current atypical MDD (β = 0.32, 95% CI 0.10–0.55) at baseline were associated with increased levels of hsCRP at follow-up. There was little evidence for inflammation markers at baseline predicting mood disorders at follow-up.

Conclusions

The prospective unidirectional association between current MDD subtype with atypical features and hsCRP levels at follow-up suggests that inflammation may be a consequence of this condition. The role of inflammation, particularly hsCRP that is critically involved in cardiovascular diseases, warrants further study. Future research that examines potential influences of medications on inflammatory processes is indicated.

Keywords

Atypical depressioncardiovascular risk factorsC-reactive proteinmood disorderspro-inflammatory cytokinesprospective study

Information

Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 6 , April 2018 , pp. 961 - 973
Copyright
Copyright © Cambridge University Press 2017 

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