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The crosstalk of hyaluronan-based extracellular matrix and synapses

Published online by Cambridge University Press:  08 October 2009

Renato Frischknecht  and
Constanze I. Seidenbecher
Renato Frischknecht*
Affiliation:
Leibniz Institute for Neurobiology, Magdeburg, Germany
Constanze I. Seidenbecher*
Affiliation:
Leibniz Institute for Neurobiology, Magdeburg, Germany
*
Correspondence should be addressed to: Renato Frischknecht or Constanze I. Seidenbecherrfrischk@ifn-magdeburg.de; seidenc@ifn-magdeburg.de
Correspondence should be addressed to: Renato Frischknecht or Constanze I. Seidenbecherrfrischk@ifn-magdeburg.de; seidenc@ifn-magdeburg.de
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Abstract

Many neurons and their synapses are enwrapped in a brain-specific form of the extracellular matrix (ECM), the so-called perineuronal net (PNN). It forms late in the postnatal development around the time when synaptic contacts are stabilized. It is made of glycoproteins and proteoglycans of glial as well as neuronal origin. The major organizing polysaccharide of brain extracellular space is the polymeric carbohydrate hyaluronic acid (HA). It forms the backbone of a meshwork consisting of CNS proteoglycans such as the lectican family of chondroitin sulphate proteoglycans (CSPG). This family comprises four abundant components of brain ECM: aggrecan and versican as broadly expressed CSPGs and neurocan and brevican as nervous-system-specific family members. In this review, we intend to focus on the specific role of the HA-based ECM in synapse development and function.

Keywords

Hyaluronic acidbrevicansynaptic plasticityextracellular matrixhyaluronidase

Information

Type
Research Article
Information
Neuron Glia Biology , Volume 4 , Special Issue 3: Cell Adhesion and Extracellular Matrix Molecules in Synaptic Plasticity , August 2008 , pp. 249 - 257
Copyright
Copyright © Cambridge University Press 2009

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