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Sensing of Oligopeptides Using Alternatively-Deposited GoldNanorods for Surface-Assisted Laser Desorption/Ionization Time-of-FlightMass Spectrometry

Published online by Cambridge University Press:  22 February 2012

Masanori Fujii ,
Naotoshi Nakashima  and
Yasuro Niidome
Masanori Fujii
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Naotoshi Nakashima
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan World Premier International (WPI) Research Center, International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan JST-CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
Yasuro Niidome
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan World Premier International (WPI) Research Center, International Institute for Carbon-Neutral Energy Research (I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
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Abstract

Gold nanorods (NRs) were fixed on an ITO plate and used for theSurface-Assisted Laser Desorption/Ionization Time-of-Flight MassSpectrometry (SALDI-MS) of oligopeptides (angiotensin I). The SALDI-MSmeasurements had a high sensitivity to the angiotensin on the ITO plate onwhich isolated NRs were deposited. Angiotensin molecules in a very dilutedsolution (1 × 10-11 M) could be detected at m/z = 1297 with agood signal/noise ratio (S/N = 18). In contrast, alternatively deposited NRan ITO plate, which present broad surface plasmon bands, was found to beinactive for SALDI measurements.

Keywords

laser ablationmass spectroscopynanostructure

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Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm03-25
Copyright
Copyright © Materials Research Society 2012

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