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Development of Bisphosphonate-Calcium Phosphate Composites andDrug Release Characteristic

Published online by Cambridge University Press:  12 April 2012

Hidekuni Kameda ,
Tomohiko Yoshioka ,
Toshiyuki Ikoma  and
Junzo Tanaka
Hidekuni Kameda
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550 Japan
Tomohiko Yoshioka
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550 Japan
Toshiyuki Ikoma
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550 Japan
Junzo Tanaka
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550 Japan
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Abstract

Bisphosphonate (Bp) was adsorbed on the surface of crystalline calciumphosphates (CP); hydroxyapatite (HAp), octacalcium phosphate (OCP) andDicalcium phosphate dehydrate (DCPD). The amount of Bp adsorbed was thelargest for DCPD per unit surface area, while the amount was the largest forHAp per unit weight. The composites of Bp and amorphous calcium phosphate(ACP) were synthesized by titrating calcium acetate solution into phosphatebuffer solution containing Bp. The amount of Bp doped in the composites was366 μg / mg and was approximately 7 times larger than those of Bp adsorbedon the crystalline Calcium phosphates. TG-DTA measurements of a Bp-calciumand the composite indicated exothermic peaks due to Bp combustion, of whichtemperature were shifted to higher temperature for the composite. Bp in thecomposites was gradually released into phosphate buffered saline, while Bpwas rapidly released into acetate buffer solution accompanied with thedissolution of ACP. This result suggests that the composite of Bp and ACPhas potential for a drug-carrier releasing Bp in response to the conditionof osteoclastic bone resorption.

Keywords

Cacompositex-ray diffraction (XRD)

Information

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-mm10-09
Copyright
Copyright © Materials Research Society 2012

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