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Complete response in a melanoma patient treated with imatinib

Published online by Cambridge University Press:  19 April 2012

M C Brown  and
R J Casasola
M C Brown
Affiliation:
Medical School, University of Dundee, Dundee, Scotland, UK
R J Casasola*
Affiliation:
Oncology Department, Ninewells Hospital, Dundee, Scotland, UK
*
Address for correspondence: Dr Richard J Casasola, Oncology Department, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK E-mail: rcasasola@nhs.net
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Abstract

Background:

Imatinib therapy has been successful in gastrointestinal stromal tumours containing mutation of the KIT gene. However, there are few reported cases of successful imatinib therapy in patients with melanoma containing KIT gene mutation or c-kit protein expression.

Methods and results:

A 52-year-old man developed metastatic melanoma from a primary melanoma in the left side of the nasopharynx. The tumour was positive for c-kit protein, and there was a KIT mutation in exon 11. He was treated with imatinib. A follow-up scan one year later showed a complete response. Treatment targeting the biological characteristics of melanoma proved successful in this patient.

Keywords

MelanomaProto-OncogenesC-kit ProteinNasopharynxAntineoplastic Agents

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 6 , June 2012 , pp. 638 - 640
Copyright
Copyright © JLO (1984) Limited 2012

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