Mood instability as a transdiagnostic predictor of cannabis use in attention-deficit/hyperactivity disorder and depression: A Natural Language Processing analysis of electronic health records from 13,025 adolescents

Asilay Seker; Edward Bullock; Susie Chandler; Rashmi Patel; Craig Colling; Diego Quattrone; Edmund J S Sonuga-Barke; Johnny Downs

doi:10.1192/j.eurpsy.2025.10095

Accepted manuscript

Mood instability as a transdiagnostic predictor of cannabis use in attention-deficit/hyperactivity disorder and depression: A Natural Language Processing analysis of electronic health records from 13,025 adolescents

Published online by Cambridge University Press: 22 August 2025

Edmund J S Sonuga-Barke and

Johnny Downs

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Asilay Seker*: Affiliation:
CAMHS Digital Lab, King’s Maudsley Partnership, King's College London and South London and the Maudsley NHS Foundation Trust, London, UK Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Edward Bullock: Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK University of Cambridge, Autism Research Centre, Cambridge, UK
Susie Chandler: Affiliation:
CAMHS Digital Lab, King’s Maudsley Partnership, King's College London and South London and the Maudsley NHS Foundation Trust, London, UK
Rashmi Patel: Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge UK
Craig Colling: Affiliation:
CAMHS Digital Lab, King’s Maudsley Partnership, King's College London and South London and the Maudsley NHS Foundation Trust, London, UK South London and the Maudsley NHS Foundation Trust, London, UK
Diego Quattrone: Affiliation:
National Institute for Health Research (NIHR) Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK South London and the Maudsley NHS Foundation Trust, London, UK Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), Psychiatry Section, University of Palermo, Palermo, Italy
Edmund J S Sonuga-Barke: Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK University of Cambridge, Autism Research Centre, Cambridge, UK
Johnny Downs: Affiliation:
CAMHS Digital Lab, King’s Maudsley Partnership, King's College London and South London and the Maudsley NHS Foundation Trust, London, UK Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK National Institute for Health Research (NIHR) Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK
*: Correspondence to: Asilay Seker, CAMHS Digital Lab, Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, 16 De Crespigny Park, London, SE5 8AF, asilayseker@gmail.com

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Abstract

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Keywords

mood instability cannabis adolescent ADHD Depression natural language processing emotion dysregulation

Information

Type: Research Article
Information: European Psychiatry , Accepted manuscript , pp. 1 - 26

DOI: https://doi.org/10.1192/j.eurpsy.2025.10095 [Opens in a new window]
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