This article traces the history of the life sciences business in the Cambridge–Boston area and explores how it became the global epicenter of the modern therapeutics industry. While business history scholarship on therapeutics is extensive, few have studied recent technological modalities—from therapeutic proteins to cell and gene therapies—or adopted a regional ecosystem perspective. Based on archival materials and oral histories, this research bridges these works and incorporates insights from the innovation ecosystems framework. It considers how dynamic interactions between an evolving network of complementary and interdependent actors, including therapeutics firms, universities, hospitals, and risk capital providers, enhanced innovative capacity. This perspective also illuminates how ecosystem strength derived from the co-evolution of actors—from universities restructuring technology transfer offices to academic scientists becoming entrepreneurs. The research further highlights the nonlinearity of innovation processes. It shows how an extraordinary interplay between structural advantage, serendipitous timing, and strategic actions cultivated an unparalleled capacity to translate emergent technologies into novel therapies.

Extant research has highlighted the impact of legal innovations on the organizational choices made by entrepreneurs and traced the diffusion of new business forms across international borders, such as the private limited liability company (PLLC). This paper uses a newly compiled database of all firms operating in Vienna between 1900 and 1936 to examine the PLLC’s impact on the Austrian business landscape following its introduction. Its findings reveal that the PLLC quickly replaced other legal forms. While suitable for a wide range of sectors, the PLLC was particularly attractive to new industries burdened by machinery investment rather than wage costs. By empirically demonstrating that the PLLC filled a critical gap in the legal framework of Austria, this study highlights the broader importance of legal forms as instruments for fostering entrepreneurial activity, shaping economic structures, and driving development.

As a source of credit on residential real estate in North America, private individuals played a vital role well into the 1950s, especially in Canada. Rare national surveys, together with varied case studies in Canada and the United States, indicate that they provided land contracts, construction loans, and first and junior mortgages to a variety of people, including family and friends and many strangers. Contacts were arranged through social networks, agents, and brokers. By comparison with major lending institutions, their role and significance have been overlooked, their loans often unrecorded. In the early decades, lenders included men and women in a range of occupations, not least because many owners offered credit to buyers to facilitate sales. By the 1950s, women, professionals, and businessmen were the main investors, the chief beneficiaries being lower-income households in less desirable districts. Some personal lenders were ill-informed or exploitive, but most enabled families to realize their aspirations to own. This sector’s decline was a consequence of federal policies that promoted national mortgage markets, making the business more professional but displacing practices that had enabled many home buyers and builders.

Business-led conservation of wildlife based on private property rights and formal governance has often yielded inconsistent results. In pursuit of alternative approaches that prioritize long-term sustainability in wildlife exploitation, this paper studies the novel case of the Nivkh people’s bear hunting enterprise, which functioned in the Lower Amur Basin and Sakhalin from the seventeenth to the early twentieth century. I demonstrate that the Nivkh ran their bear enterprise sustainably via a conglomeration of traditional ecological knowledge, religious beliefs, and informal social institutions, satisfying their personal demand for the animal while successfully selling bear furs and gallbladders to foreign merchants. Such developments were also supported by the regional political economy in which the Nivkh retained a large degree of autonomy. The paper highlights the productive impact that ideas of sacrality, human–animal kinship, and reciprocity exert on sustainability in wildlife enterprises while also stressing the importance of careful government policy in relation to Indigenous conservation systems. The study validates its claims through field notes, expeditionary journals, state reports, and historical and ethnographic research.