We prove that a ring R is an $n \times n$ matrix ring (that is, $R \cong \mathbb {M}_n(S)$ for some ring S) if and only if there exists a (von Neumann) regular element x in R such that $l_R(x) = R{x^{n-1}}$. As applications, we prove some new results, strengthen some known results and provide easier proofs of other results. For instance, we prove that if a ring R has elements x and y such that $x^n = 0$, $Rx+Ry = R$ and $Ry \cap l_{R}(x^{n-1}) = 0$, then R is an $n \times n$ matrix ring. This improves a result of Fuchs [‘A characterisation result for matrix rings’, Bull. Aust. Math. Soc. 43 (1991), 265–267] where it is proved assuming further that the element y is nilpotent of index two and $x+y$ is a unit. For an ideal I of a ring R, we prove that the ring $(\begin {smallmatrix} R & I \\ R & R \end {smallmatrix})$ is a $2 \times 2$ matrix ring if and only if $R/I$ is so.