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The anhedonia hypothesis: Mark III

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Commentary onWiseRoy A. (1982) Neuroleptics and operant behavior: The anhedonia hypothesis. BBS 5:39–87.

Published online by Cambridge University Press:  04 February 2010

Roy A. Wise
Roy A. Wise
Affiliation:
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, P.O., Canada H3G 1M8
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Behavioral and Brain Sciences , Volume 8 , Issue 1 , March 1985 , pp. 178 - 186
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Copyright © Cambridge University Press 1985

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References

Ahlenius, S. (1973) Inhibition of catecholamine synthesis and conditioned avoidance acquisition. Pharmacology. Biochemistry and Behavior 1:347–50. [SA]CrossRefGoogle ScholarPubMed
Ahlenius, S. (1978) Potentiation by haloperidol of the catalepsy produced by lesions in the parafascicular nucleus of the rat. Brain Research 150:646–52. [SA]CrossRefGoogle ScholarPubMed
Ahlenius, S. (1979) An analysis of behavioural effects produced by drug-induced changes in dopaminergie neurotransmission in the brain. Scandinavian Journal of Psychology 20:59–64. [SA, rRAW]CrossRefGoogle Scholar
Ahlenius, S. (1980) Enhanced suppression of a. conditioned avoidance response by haloperidol but not phenoxyhenzamine in rats with bilateral parafaseieular lesions. Experimental Brain Research 40:164–69. [SA]CrossRefGoogle Scholar
Ahlenius, S. & Engel, J.(1971) Effects of small doses of haloperidol on timing behaviour. Journal of Pharmacy and Pharmacology 23:301–2. [SA]CrossRefGoogle Scholar
Ahlenius, S., Engel, J. & Zöller, M. (1977) Effects of apomorphine and haloperidol on exploratory behavior and latent learning in mice. Physiological Psychology 5:290–94. [SA]CrossRefGoogle Scholar
Anlezark, C. M., Arbuthnott, G. W., Christie, J. E., & Crow, T. J. (1971) Role of cerebral dopamine in the action of psychotropie drugs. British Journal of Pharmacology 41:406P. [TJC]Google ScholarPubMed
Atalay, J., Bozarth, M. A. & Wise, R. A. (1982) Task-independent reward and performance shifts from phnozide in self-stimulationg rats. Paper presented at the annual meeting of the Canadian Psychological Association. Montreal. [rRAW]Google Scholar
Atrens, D. M. (1970) Reinforeing and emotional consequences of electrical self-stimulation of the subcortical limbic forebrain. Physiology and Behavior 5:1461–71. [AJG]CrossRefGoogle ScholarPubMed
Atrens, D. M., Ljungberg, T. & Ungerstedt, U.(1976). Modulation of reward and aversion processes in the rat diencephalon by neuroleptics: Differential effects of clozapine and haloperidol. Psychopharmacology 49:97–100. [AJC]CrossRefGoogle ScholarPubMed
Beninger, R. J. (1982) The behavioral function of dopamine. Behavioral and Brain Sciences 5:55–56. [rRAW]CrossRefGoogle Scholar
Beninger, R. J. (1983) The role of dopamine in locomotor activity and learning. Brain Research Reviews 6:173–96. [rRAW]CrossRefGoogle Scholar
Bindra, D. (1974) A motivational view of learning, performance. and behavior modification. Psychological Review 81:199–213. [rRAW]CrossRefGoogle ScholarPubMed
Bindra, D. (1978) How adaptive behaviour is produced: A perceptual-motivational alternative to response-reinforcement. Behavioral and Brain Sciences 1:41–91. [rRAW]CrossRefGoogle Scholar
Bolles, R. C. (1972) Reinforcement, expectancy, and learning. Psychological Review 79:394–409. [rRAW]CrossRefGoogle Scholar
Bradley, P. B. (1958) The central action of certain drugs in relation to the reticular formation. In: Reticular formation of the Brain, ed. Jasper, A. H., Proctor, L. D., Knighton, R. S.. Noshay, W. C. & Costello, R. T.. Little Brown & Co. [CK]Google ScholarPubMed
Cabanac, M. (1971) Physiological role of pleasure. Science 173:1103–07. [rRAW]CrossRefGoogle ScholarPubMed
Cabanac, M. (1979) Sensorv pleasure. Quarterly Review of Biology 54:1–29. [EK]CrossRefGoogle ScholarPubMed
Coons, E. E. & White, H. A. (1977) Tonic properties of orosensation and the modulation of intracranial self-stimulation: The CNS weighting of external and internal factors governing reward. Annals of the Sew York Academy of Sciences 290:158–79. [EK]CrossRefGoogle ScholarPubMed
Cooper, B. R., Cott, J. M. & Breese, G. R. (1974) Effects of catecholaminedepleting drugs and amphetamine on self-stimulation of brain following various 6-hydroxydopamine treatments. Psychopharmacologia 248:235–48. [rRAW]CrossRefGoogle Scholar
Coppen, A., Metealfe, M., Carroll, J. D. & Morris, J. G. L. (1972) Levodopa and L-tryptophan therapy in Parkinsonism. Lancet 1:654–58. [TJC]CrossRefGoogle ScholarPubMed
Crow, T. J. (1968) Cortical synapses and reinforcement: A hypothesis. Nature 219:736–37. [TJC]CrossRefGoogle ScholarPubMed
Crow, T. J. (1971) The relation between electrical self-stimulation sites and catecholamine-containing neurones in the rat mesencephalon. Experientia 27:662. [TJC]CrossRefGoogle ScholarPubMed
Crow, T. J. (1972b) A map of the rat mesencephalon for electrical self-stimulation. Brain Research 36:265–73. [TJC]CrossRefGoogle ScholarPubMed
Crow, T. J. (1973) Catecholamine-containing neurones and electrical self-stimulation. 2. A theoretical interpretation and some psychiatric implications. Psychological Medicine 3:66–73. [TJC, rRAW]CrossRefGoogle ScholarPubMed
Crow, T. J. (1972a) Catecholamine-containing neurones and electrical self-stimulation. I. A review of some data. Psychological Medicine 2:414–21. [TC]CrossRefGoogle Scholar
Crow, T. J. (1979) Catecholamine reward pathways and sehizophrenia: The mechanism of the antipsychotic effects and the site of the primary disturbance. Federation Proceedings 38:2462–67. [CK]Google ScholarPubMed
Crow, T. J. & Wendlaudt, S. (1976) Impaired acquisition of a passive avoidance response after lesions induced in the locus coerulcus by 6-OM-dopamine. Suture 259:42–44. [TJC]Google Scholar
Edmonds, D. E. & Gallistel, C. R. (1974) Parametric analysis of brain stimulation reward in the rat: 3. Effect of performance variables on the reward summation function. Journal of Comparative and Physiological Psychology 87:876–83. [rRAW]CrossRefGoogle Scholar
Esposito, R. U., Faulkner, W. & Kometsky, C. (1979) Specific modulation of brain stimulation reward by haloperidol. Pharmacology, Biochemistry and Behavior 10:937–40. [rRAW]CrossRefGoogle ScholarPubMed
Ettenberg, A. (1982) Behavioral effects of neuroleptics: Performance deficits, reward deficits or both? Behavioral and Brain Sciences 5:56–57. [rRAW]CrossRefGoogle Scholar
Ettenberg, A., Koob, C. G. & Bloom, F. E. (1981) Response artificact in the measurement of neuroleptic-induced anhedonia. Science 209: 357–59. [TS]CrossRefGoogle Scholar
Fantie, B. D. & Nakajíma, S. (1984) A task for assessing brain stimulation with minimum motor involvement. Paper presented at the annual meeting of the Canadian Psychological Association, Ottawa. [rRAW]Google Scholar
Fouriezos, G., Hansson, P. & Wise, R. A. (1978) Neuroleptie-indnced attenuation of brain stimulation reward. Journal of Comparative and Physiological Psychology 92:659–69. [GF, rRAW]CrossRefGoogle ScholarPubMed
Fouriezos, G. & Wise, R. A. (1976) Pimozide-induced extinction of intracranial self-stimulation: Response patterns rule out motor or performance deficits. Brain Research 103:377–80. [GF, rRAW]CrossRefGoogle ScholarPubMed
Fowler, S. C., Filcwieh, R. J. & Leberer, M. R. (1977) Drug effects upon force and duration of response during fixed-ratio performance in rats. Pharmacology, Biochemistry and Behavior 6:421–26. [AJG]CrossRefGoogle ScholarPubMed
Franklin, K. B. J. (1978) Catecholamines and self-stimulation: Reward and performance deficits dissociated. Pharmacology, Biochemistry and Behavior 9:813–20. [rRAW]CrossRefGoogle Scholar
Franklin, K. B. J. & McCoy, S. N. (1979) Pimozide-induced extinction in rats: Stimulus control of responding rules out motor deficit. Pharmacology, Biochemistry and Behavior 11:71–76. [GF, rRAW]CrossRefGoogle ScholarPubMed
Freed, W. J. & Zee, R. F. (1982) Criteria for ruling out sedation as an interpretation of neuroleptic effects. Behavioral and Brain Sciences 5:57–59. [GF]CrossRefGoogle Scholar
Gallistel, C. R. (1983) The empirical and theoretical justification for the use of the curve-shift method in drug and lesion experiments. Paper presented at the Society for Neuroseience Sattelite Symposium: ESB and Brain Mechanisms of reward, Boston. [rRAW]Google Scholar
Gallistel, C. R., Boytim, M., Gomita, Y. & Klebanoff, L. (1982) Docs pimozide block the reinforcing effect of brain stimulation? Pharmacology, Biochemistry and Behavior 17:769–81. [rRAW]CrossRefGoogle Scholar
Gallistel, C. R., Shizgal, P. & Yeomans, J. (1981) A portrait of the substrate for self-stimulation. Psychological Review 88:228–73.CrossRefGoogle ScholarPubMed
Gerber, G. J., Sing, J. & Wise, R. A. (1981) Pimozide attenuates lever pressing for water in rats. Pharmacology, Biochemistry and Behavior 14:201–05. [rRAW]CrossRefGoogle ScholarPubMed
German, D. C. (1982) Dopamine neurons, reward and behavior. Behavioral and Brain Sciences 5:59–60. [rRAW]CrossRefGoogle Scholar
German, D. C. & Bowden, D. M. (1974) Catecholamine systems as the neural substrate for intracranial self-stimulation: A hypothesis. Brain Research 73:381–419. [rRAW]CrossRefGoogle ScholarPubMed
Gramling, S. E., Fowler, S. C. & Collins, K. R. (1984) Nondeprived animals lieking a sucrose solution fail to exhibit “anhedonia” with repeated administrations of pimozide. Pharmacology, Biochemistry and Behavior. In press. [rRAW]Google Scholar
Gray, T. & Wise, R. A. (1980) Effects of pimozide on lever-pressing behavior maintained on an intermittent reinforcement schedule. Pharmacology, Biochemistry and Behavior 12:931–35. [rRAW]CrossRefGoogle Scholar
Greenshaw, A. J. (1981) Effects of drugs on reward in rats. Ph.D. thesis. University of Wales. [AJG]Google Scholar
Greenshaw, A. J., Sanger, D. J. & Blackman, D. E. (1981) The effects of pimozide and of reward omission on fixed-interval behaviour of rats maintained by food and electrical brain stimulation. Pharmacology, Biochemistry and Behavior 15:227–33. [AJG]CrossRefGoogle ScholarPubMed
Greenshaw, A. J.(1983). The effects of ehlordiazepoxide on the self-regulated duration of lateral hypothalamic stimulation in rats. Psychophannacology 81:236–38. [AJG]CrossRefGoogle ScholarPubMed
Gunne, L. M., Anggard, E. & Jonsson, L. E. (1972) Clinical trials with amphetamine-blocking drugs. Psychiatria Neurologia Neurochirurgia 75:225–26. [rRAW]Google ScholarPubMed
Herberg, L. J., Stephens, D. N. & Franklin, K. B. J. (1976) Catecholamines and self-stimulation: Evidence suggesting a reinforcing role for noradrenaline and a motivating role for dopamine. Pharmacology, Biochemistry and Behavior 4:575–82. [rRAW]CrossRefGoogle Scholar
Homykiewiez, O. (1976) Neurohumoral interactions and basal ganglia function and dysfunction. In: The basal ganglia, ed. Yahr, M. D.. Raven Press. [SA]Google Scholar
Huston, J. P., Grimm, C. & Omstein, K. (1984) Self-stimulation in the brain stem after ipsilateral precollicular deeerebration. Experimental Neurology 83:568–76. [TS]CrossRefGoogle Scholar
Katz, R. J. (1982) Dopamine and the limits of behavioral reduction or why aren't all schizophrenics fat and happy? Behavioral and Brain Sciences 5:60–61. [rRAW]Google Scholar
Killam, K. F. & Killam, E. K. (1958) Drug action on pathways involving the reticular formation. In: Reticular formation of the brain, ed. Jasper, A. H., Proctor, L. D., Knighton, R. S., Noshay, W. C. & Costello, R. T.. Little Brown & Co. [CK]Google Scholar
Kornetsky, C. & Eliasson, M. (1969) Reticular stimulation and chlorpromazine: An animal model for schizophrenic overarousal. Science 165:1273–74. [CK]CrossRefGoogle ScholarPubMed
Kornetsky, C. & Markowitz, R. (1978) Animal models of schizophrenia. In: Psychophannacology: A generation of progress, ed. Lipton, M. A., DiMascio, A. & Killam, K. F.. Raven Press. [CK]Google Scholar
Kostarczyk, E. (1980) Autonomic changes accompanying instrumental responses and alimentary reinforcement. Seventh International Conference on the Physiology of Food and Fluid Intake “IUPS,” Warsaw. [EK]Google Scholar
Kostarczyk, E. & Fonberg, E. (1980) Tactile stimulation as an important factor involved in social motivation. Neurosciences Letters Supp. 5:S318 [EK]Google Scholar
Kostarczyk, E. (1982) Autonomic responses accompanying conditioned and unconditioned alimentary reactions in amygdalo-hypothalamically lesioned dogs. Acta Neurobiologiae Experimentalis 42:43–58. [EK]Google ScholarPubMed
Kostarczyk, E. (1982) Characteristics of the heart rate in relation to the palatability of food in dogs. Appetite 3:321–28. [EK]CrossRefGoogle Scholar
Liebman, J. M. & Butcher, L. L. (1973) Effects on self-stimulation behavior of drugs influencing dopaminergic neurotransmission mechanisms. Naunyn-Schtnicdebcrg's Archives of Pharmacology 277:305–18. [rRAW]CrossRefGoogle ScholarPubMed
Liebman, J. M. & Butcher, L. L. (1974) Comparative involvement of dopamine and noradrenaline in rate-free self-stimulation in substantia nigra, lateral hypothalamus, and mesencephalic central gray. Naunyn Schmiedeberg's Archicves of Pharmacology 284:167–194. [rRAW]CrossRefGoogle ScholarPubMed
Lippa, A. S., Antelman, S. M., Fisher, A. E. & Canfield, D. R. (1973) Neurochemical mediation of reward: A significant role for dopamine? Pharmacology, Biochemistry and Behavior 1:23–28. [rRAW]CrossRefGoogle ScholarPubMed
Lyon, M. & Randrup, A. (1972) The dose-response effect of amphetamine upon avoidance behaviour in the rat seen as a function of increasing stereotypy. Psychopharmacologia 23:334–47. [AJG]CrossRefGoogle ScholarPubMed
Major, R. & White, N. (1978) Memory facilitation by self-stimulation reinforcement mediated by the nigro-neostriatal bundle. Physiology and Behavior 20:723–33. [rRAW]CrossRefGoogle ScholarPubMed
Malmo, R. B. & Malmo, H. P. (1982) Wise's neural model implicating the reticular formation: Some queries. Behavioral and Brain Sciences 5:66–68. [rRAW]CrossRefGoogle Scholar
Marshall, J. F., Levitan, D. & Strieker, E. M. (1976) Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions. Journal of Comparative and Physiological Psychology, 90:536–46. [TJC]CrossRefGoogle ScholarPubMed
Mindham, R. H. S. (1970) Psychiatric symptoms in Parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 33:188–91. [TJC]CrossRefGoogle ScholarPubMed
Mogenson, G. J., Takigawa, M., Robertson, A. & Wu, M. (1979) Self stimulation of the nucleus accumbens and ventral tegmental area of Tsai attenuated by microinjections of spiroperidol into the nucleus accumbens. Brain Research 171:247–54. [AJG]CrossRefGoogle ScholarPubMed
Mowrer, O. H. (1960) Learning theory and behaviour. John Wiley and Sons. [EK]CrossRefGoogle Scholar
Neill, D. (1982) Problems of concept and vocabulary in the anhedonia hypothesis. Behavioral and Brain Sciences 5:70. [rRAW]CrossRefGoogle Scholar
Nemeroff, C. B. & Luttinger, D. (1982) The anhedonia hypothesis of neuroleptic drug action: Basic and clinical considerations. Behavioral and Brain Sciences 5:70–71. [rRAW]CrossRefGoogle Scholar
Olds, J. & Milner, P. M. (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. Journal of Comparative and Physiological Psychology 47:419–27. [AJG, rRAW]CrossRefGoogle ScholarPubMed
Olds, J. & Travis, R. P. (1960) Effects of ehlorpromazine, meprobamate, pentobarbital and morphine on self-stimulation. Journal of Pharmacological and Experimental Therapeutics 128:397–404. [TJC]Google ScholarPubMed
Olds, M. E. (1975) Effects of intraventricular 6-hydroxydopamine and replacement therapy with norepinephrine, dopamine and serotonin on self-stimulation in diencephalic and mesencephalic regions in the rat. Brain Research 98:327–42. [AJG]CrossRefGoogle ScholarPubMed
Panksepp, J. (1982) The pleasure in brain substrates of foraging. Behavioral and Brain Sciences 5:71–72. [rRAW]CrossRefGoogle Scholar
Pickens, R. & Harris, W. C. (1968) Self-administration of d-amphetamine by rats. Psychopharmacologia 12:158–63. [rRAW]CrossRefGoogle ScholarPubMed
Rech, R. H. (1982) Neurolepsis: Anhedonia or blunting of emotional reactivity? Behavioral and Brain Sciences 5:72–73. [rRAW]CrossRefGoogle Scholar
Redgrave, P. (1978) Modulation of intracranial self-stimulation behaviour by local perfusions of dopamine, noradrenaline and serotonin within the caudate nucleus and nucleus accumbens. Brain Research 155:277–95. [AJG]CrossRefGoogle ScholarPubMed
Robin, A. H. (1976) Depression in patients with Parkinsonism. British Journal of Psychiatry 128:141–45. [TJC]CrossRefGoogle Scholar
Sanger, D. J. (1978) Effects of d-amphetamine on temporal and spatial discrimination in rats. Psyclwphannacology 58:185–88. [AJG]CrossRefGoogle ScholarPubMed
Schaefer, G. J. & Michael, R. P. (1980) Acute effects of neuroleptics on brain self-stimulation thresholds in rats. Psychopharmacology 67:9–15. [rRAW]CrossRefGoogle ScholarPubMed
Seeman, P. (1980) Brain dopamine receptors. Pharmacological Reviews 32:229–313. [SA]Google ScholarPubMed
Skinner, B. F. (1935a) The generic nature of the concepts of stimulus and response. Journal of General Psychology 12:40–65. [rRAW]CrossRefGoogle Scholar
Skinner, B. F. (1935b) Two types of conditioned reflex and a pseudotype. Journal of General Psychology 12:66–77. [rRAW]CrossRefGoogle Scholar
Solomon, P. R. & Crider, A. (1982) Attention, dopamine, and schizophrenia. Behavioral and Brain Sciences 5:75–76. [rRAW]CrossRefGoogle Scholar
Soubrié, P. (1982) Neuroleptic-induced anhedonia: Some psychopharmacological implications. Behavioral and Brain Sciences 5:76–77. [rRAW]CrossRefGoogle Scholar
Stein, L. (1978) Reward transmitters: Catecholamines and opioid peptides. In: Psychopharmacology: A generation of progress, ed. Lipton, M. A., Mascio, A. D. & Killam, K. F.. Raven Press. [AJG]Google Scholar
Stein, L. (1980) The chemistry of reward. In: Biology of reinforcement: Facets of brain stimulation reward, ed. Routtenberg, A.. Academic Press. [rRAW]Google Scholar
Stein, L. & Belluzzi, J. D. (1979) Brain endorphins: Possible role in reward and memory formation. Federation Proceedings 38:2468–72. [CK]Google ScholarPubMed
Stein, L. & Ray, O. S. (1960) Brain stimulation reward “thresholds” self-determined in rats. Psychopharmacologia 1:251–56. [AJG]CrossRefGoogle Scholar
Stein, L. & Wise, C. D. (1971) Possible etiology of schizophrenia: Progressive damage to the noradrenergic reward systems by 6-hydroxydopainine. Science 171:1032–36. [CK]CrossRefGoogle Scholar
Stellar, J. R., Kelley, A. E. & Corbett, D. (1983) Effects of peripheral and central dopamine blockade on lateral hypothalamic self-stimulation: Evidence for both reward and motor deficits. Pharmacology, Biochemistry and Behavior 18:433–42. [rRAW]CrossRefGoogle ScholarPubMed
Thompson, R. (1963) Thalamic structures critical for retention of an avoidance conditioned response in rats. Journal of Comparative and Physiological Psychology 56:261–67. [SA]CrossRefGoogle ScholarPubMed
Ungerstedt, U. (1974) Brain dopamine neurons and behaviour. In: The neurosciences: Third study program, ed. Schmitt, F. O. & Worden, F. G.. MIT Press. [TJC]Google Scholar
Valenstein, E. S. (1964) Problems of measurement and interpretation with reinforcing brain stimulation. Psychological Review 71:415–37. [AJG, TS, rRAW]CrossRefGoogle ScholarPubMed
Vanderwolf, C. H. (1962) Medial thalamic functions in voluntary movement. Canadian Journal of Psychology 16:318–30. [SA]CrossRefGoogle Scholar
White, N. & Major, R. (1978) Effect of pimozide on the improvement in learning produced by self-stimulation and by water reinforcement. Pharmacology, Biochemistry and Behavior 8:565–71. [rRAW]CrossRefGoogle ScholarPubMed
Wise, R. A. (1978) Catecholamine theories of reward: A critical review. Brain Research 152:215–47. [AJG]CrossRefGoogle ScholarPubMed
Wise, R. A. (1978) Neuroleptic attenuation of intracranial self-stimulation: Reward of performance deficits? Life Science 22:535–42. IrRAW]CrossRefGoogle ScholarPubMed
Wise, R. A. (1982a) Hypotheses of neuroleptic action: Levels of progress. Behavioral and Brain Sciences 5:78–82. [rRAW]CrossRefGoogle Scholar
Wise, R. A. (1982b) Neuroleptics and operant behavior: The anhedonia hypothesis. Behavioral and Brain Sciences 5:39–53. [SA, TJC, AJG, CK, EK, TS, rRAW]CrossRefGoogle Scholar
Wise, R. A. & Colic, L. (1984) Pimozide attenuates free feeding: Best scores analysis reveals a motivational deficit. Psychophannacology 84: 446–51. [rRAW]CrossRefGoogle ScholarPubMed
Wise, R. A., Spindler, J., deWit, H. & Gerber, G. J. (1978a) Neurolepticinduced “anhedonia” in rats: Pimozide blocks reward quality of food. Science 201:262–64. [rRAW]CrossRefGoogle ScholarPubMed
Wise, R. A., Spindler, J. & Legault, L. (1978b) Major attenuation of food reward with performance-sparing doses of pimozide in the rat. Canadian Journal of Psychology 32:77–85. [rRAW]CrossRefGoogle ScholarPubMed
Wyrwicka, W. (1975) The sensory nature of reward in instrumental behaviour. Pavlovian Journal of Biological Sciences 10:23–51. [EK]CrossRefGoogle Scholar
Zarevics, P. & Setler, P. E. (1979) Simultaneous rate-independent and ratedependent assessment of intracranial self-stimulation: Evidence for the direct involvement of dopamine in brain reinforcement mechanisms. Brain Research 169:449–512. [AJG, rRAW]CrossRefGoogle ScholarPubMed