From genome sequencing to large sky surveys, digital technologies produce massive datasets that promise unprecedented scientific insights. But data, for being good to use and reuse, need people – scientists, technicians, and administrators – as embodied, evaluative, social humans. In this book, anthropologist Götz Hoeppe draws on an ethnography of astronomical research to examine the media and practices that scientists and technicians use to instruct graduate students, make diagrams for data calibration and discovery, organize collaborative work, negotiate the ethics of open access, encode their knowledge in datasets – and do social inquiries along the way. This book offers a reflection on the sociality of data-rich research that will benefit attempts to integrate human and machine learning. It is essential reading for anyone interested in data science, science and technology studies, as well as the anthropology, sociology, history, and philosophy of science. This book is also available Open Access on Cambridge Core.